PeatThemAll
Member
- Joined
- Oct 3, 2015
- Messages
- 280
Collateral fattening: When a deficit in lean body mass drives overeating
Abstract
"In his last review entitled “Some Adventures in Body Composition,” Gilbert Forbes reminded us that “lean body mass and body fat are in a sense companions.” To what extent the lean body mass (or fat-free mass) component in this companionship impacts on energy intake is rarely a topic for discussion, amid a dominant adipocentric view of appetite control. Yet an analysis of the few human studies that have investigated the relationships between objectively measured food intake and body composition reveals a potentially important role for both an increase and a decrease in fat-free mass in the drive to eat. These studies are highlighted here, together with the implications of their findings for research directed as much toward the elucidation of peripheral signals and energy-sensing mechanisms that drive hunger and appetite, as toward understanding the mechanisms by which dieting and sedentariness predispose to fatness."
Conclusion
"In line with the remarks of Gilbert Forbes [13] that FM and FFM are “companions,” the body's attempt to restore FFM by increasing energy intake will inevitably result in an accompanying increase in body fat. To what extent this phenomenon of “collateral fattening” will keep operating over time in situations of limited capacity to rebuild lean tissues (e.g., in older age, feeding on poor-quality diets) and underlie certain forms of sarcopenic obesity are also intriguing questions for future research to address. Overall, the phenomenon of collateral fattening is a further reminder of the importance of promoting both healthy diets and physical activity as protection against FFM deficits in strategies directed at both the prevention and treatment of obesity."
Abstract
"In his last review entitled “Some Adventures in Body Composition,” Gilbert Forbes reminded us that “lean body mass and body fat are in a sense companions.” To what extent the lean body mass (or fat-free mass) component in this companionship impacts on energy intake is rarely a topic for discussion, amid a dominant adipocentric view of appetite control. Yet an analysis of the few human studies that have investigated the relationships between objectively measured food intake and body composition reveals a potentially important role for both an increase and a decrease in fat-free mass in the drive to eat. These studies are highlighted here, together with the implications of their findings for research directed as much toward the elucidation of peripheral signals and energy-sensing mechanisms that drive hunger and appetite, as toward understanding the mechanisms by which dieting and sedentariness predispose to fatness."
Conclusion
"In line with the remarks of Gilbert Forbes [13] that FM and FFM are “companions,” the body's attempt to restore FFM by increasing energy intake will inevitably result in an accompanying increase in body fat. To what extent this phenomenon of “collateral fattening” will keep operating over time in situations of limited capacity to rebuild lean tissues (e.g., in older age, feeding on poor-quality diets) and underlie certain forms of sarcopenic obesity are also intriguing questions for future research to address. Overall, the phenomenon of collateral fattening is a further reminder of the importance of promoting both healthy diets and physical activity as protection against FFM deficits in strategies directed at both the prevention and treatment of obesity."