Coffee polyphenols ameliorate cognitive decline via maintenance of blood-brain barrier (BBB) integrity in senescence-accelerated mouse prone 8 (SAMP8)

cupofcoffee

Member
Joined
Jul 31, 2020
Messages
86
The blood-brain barrier (BBB) plays crucial roles for the maintenance of brain homeostasis. Recent findings demonstrate that BBB breakdown proceeds the onset of cognitive decline in dementia such as Alzheimer’s disease (AD). We have previously reported that coffee polyphenols (CPP) prevent cognitive dysfunction in APP/PS2 AD mouse model. However, the effects of CPP on age-related cognitive decline and BBB impairment remain unknown. In the present study, we investigated the effects of CPP diet for 8 months on age-related cognitive decline in senescence-accelerated mouse prone 8 (SAMP8) mice. Hippocampal BBB permeability was assessed by using Na-F dye. The protein expression of tight junctions (Claudin-5, Occludin) and synaptic markers (Synaptophysin, PSD-95) were measured by western blotting. BDNF concentration was examined by ELISA. The cognitive function was evaluated by novel object recognition test. Long-term ingestion of CPP significantly reduced BBB permeability and increased the Claudin-5 expression. Synaptic proteins and BDNF in hippocampus were also increased by CPP ingestion. Furthermore, significant positive correlations were observed between the expression of Claudin-5 and synaptic proteins, indicating that maintenance of BBB integrity by CPP might protects synaptic proteins. Moreover, the cognitive function was markedly improved by CPP treatment. These results suggest that long-term ingestion of CPP prevents age-related neuronal deficit and cognitive decline via maintenance of BBB integrity.
 

Korven

Member
Joined
May 4, 2019
Messages
377
Thanks for posting.

I really think coffee is the ultimate longevity beverage. My 70 year old dad basically lives off of sandwiches and never works out, but he drinks tons and tons of coffee every day and has done so his entire life. He's barely got any wrinkles, youthful skin almost. Very sharp-witted and no signs of cognitive decline. I'm amazed at how well he's holding up considering he doesn't give a crap about health and nutrition.
 

cupofcoffee

Member
Thread starter
Joined
Jul 31, 2020
Messages
86
Thanks for posting.

I really think coffee is the ultimate longevity beverage. My 70 year old dad basically lives off of sandwiches and never works out, but he drinks tons and tons of coffee every day and has done so his entire life. He's barely got any wrinkles, youthful skin almost. Very sharp-witted and no signs of cognitive decline. I'm amazed at how well he's holding up considering he doesn't give a crap about health and nutrition.
Yeah coffee is godsend, even mainstream medicine agrees that it can be beneficial to health.
 
Similar threads
Thread starter Title Forum Replies Date
R Habitual coffee drinkers display a distinct pattern of brain functional connectivity Scientific Studies 3
bzmazu I like this German article on coffee... Caffeine 3
A Is it worth to avoid from coffee? Ask For Help or Advice 19
L Suddenly unable to tolerate coffee Digestion 11
cupofcoffee Post-diagnostic coffee and tea consumption and breast cancer survival Coffee 0
Lokzo Teacrine Benefits: An Alternative To Caffeine/Coffee Supplements 0
E McDonalds coffee Coffee 6
G Coffee enema vs normal enema for constipation Ask For Help or Advice 20
P Made one change to coffee, now no more stress Coffee 23
Stifler Extreme Stress Reaction from Coffee and Orange juice taken too close? Coffee 3
T I can barely smell anything after drinking coffee. Is this normal? Diet 3
bookshelf Blender Coffee with Egg, including variations Coffee 0
J How does Ray Peat make coffee? Ask For Help or Advice 8
Mr.Cacciatore Carrots salad with Coffee Carrot Salad, Bamboo Shoots, Mushrooms 0
IVILA Coffee Causing Bloating, Burping, Gas Coffee 18
jamies33 My Experience With Coffee After 3 Years Of Daily (ab)use Coffee 5
A Coffee Completely Reversing Flu Symptoms In A Matter Of Minutes? Coffee 5
metabolizm Coffee & Constipation Ask For Help or Advice 8
J Hot Tea > Hot Coffee As Thermogenic Hydration Stimulus Beverages, Fruits, Sugars 0
D Sugar In Morning Coffee Difficulty Breathing? Blood Sugar 10
lvysaur Guy Sees His RBCs Under Microscope After Coffee Coffee 6
R J Coffee Reliably Raises Temp And Makes Me Feel Great Ask For Help or Advice 1
D Coffee,Milk Plus Aspirin And MB Male Issues 2
E Does Coffee Make You Fat And Anxious? Miscellaneous 12
A Would Drinking Coffee Along With Turmeric Inhibit Iron Absorption? Ask For Help or Advice 5
E Coffee Associated With Improved Survival In Metastatic Colorectal Cancer Patients Scientific Studies 0
M Personal Anecdotal Evidence Re: Coffee Consumption And Height Miscellaneous Health Discussions 45
J Quiting Coffee - Decreased Appetite / Mobilizing FFA / Urinary Catecholamine Excretion Diet, Recipes 8
A Coffee Causes Diarrhea Ask For Help or Advice 9
Twohandsondeck Panera Bread Offers 32 Ounces Of Coffee Every 2 Hours For 90 Days For Free Society 1
J Coffee Sourcing Brands & Location Diet, Recipes 3
F Can Coffee Raise TSH? Coffee 1
Light Ice Coffee Slushy - Easy! Recipes 0
Bogdar I Think Coffee Can Produce Other Kind Of Stimulating Effects Coffee 0
A Stinky Farts After Coffee Ask For Help or Advice 1
I High Adrenaline? Wake Up Pretty Warm But Cold Hands And Feet Right After Coffee Or Bf Metabolism 7
Twohandsondeck Making Coffee Even More Pro-thyroid With Seaweed (tasteless) Coffee 0
M Coffee And Cortisol Caffeine 1
Pieter Stress, Coffee, Wellbutrin, Sleep And Gelatin Blood Sugar 2
E Coffee Linked To Lower Body Fat In Women Scientific Studies 0
T Self-experiment: Feeling Great After 2 Weeks Of No Coffee Or White Sugar Coffee 75
metabolizm Love For Instant Coffee Diet, Recipes 6
E How To Make The Healthiest Coffee, According To Science Scientific Studies 0
BearWithMe Fitlered Coffee Decreases All-cause Mortality, Unfiltered Not Scientific Studies 18
RealNeat Testicular Pain Upon Drinking Coffee? Ask For Help or Advice 0
H Coffee Without Glycine Allergy Diet 2
A Brain Fog/sleepines After Coffee. Problems With Blood Flow/sulphur? Ask For Help or Advice 7
Constatine Coffee To Sterilize The Gut Scientific Studies 24
W “The Pleasures And Pains Of Coffee” By Honore De Balzac The Ray Peat Forum Lounge 8
C What Coffee To Buy? Coffee 18

Similar threads

Top