Sci-Hub | Beyond Caffeine: Coffee Contains Opioid Antagonists | 10.1089/jcr.2014.0024
I think this explains why I get an urge to drink coffee after consuming dietary opioid peptides such as gluten exorphins and casein's casomorphins, and that it relieves feelings of uneasiness and stupor.
1983, Boubliket al. screened common foodstuffs for opiate receptor binding activity and reported that both normal and decaffeinated coffee contain compounds with binding affinity comparable to that of naloxone.2 These compounds are unrelated to caffeine and were shown to be antagonistic and specific for opiate-induced inhibition of twitch in rats. In the past decade, researchers at the Vanderbilt Institute for Coffee Studies (VICS) have identified these compounds—including 4-Caffeoyl-1,5-quinide (4-CQL)—which are created in the roasting process and ‘‘show in-vivo inhibition of morphine-induced anti-nociceptive behavior in mice with the same order of magnitude as that reported for naloxone.’’3
I think this explains why I get an urge to drink coffee after consuming dietary opioid peptides such as gluten exorphins and casein's casomorphins, and that it relieves feelings of uneasiness and stupor.