nullredvector
Member
Some enzymes or enzyme complexes require several cofactors. For example, the multienzyme complex pyruvate dehydrogenase[5] at the junction of glycolysis and the citric acid cyclerequires five organic cofactors and one metal ion: loosely bound thiamine pyrophosphate (TPP), covalently bound lipoamide and flavin adenine dinucleotide (FAD), and the cosubstrates nicotinamide adenine dinucleotide (NAD+) and coenzyme A (CoA), and a metal ion (Mg2+). -Wiki
@haidut has mentioned PDH many times and it is a very important enzyme, which leads me to believe it's cofactors are very important too. Personally, if I go without lipoic acid I get excessive urination and my neuropathy flairs a bit. We all know how important Magnesium and niacinamide are. I don't know how important dietary B5 is (precursor for CoA). B1 also helps me tremendously.
What about B2 or more importantly active B2 or FAD. I wonder if there is any benefit to the active form (supp here). I seem to just pee out all the B2 I take but I have read elsewhere that a burdened liver has a hard time activating B vitamins. Any truth to that? Worth trying that supp out? What about B5?