Cod-liver Oil Inhibits Gastric Secretion

[meatbag]

THE EFFECT OF OLIVE OIL AND OF COD LIVER OIL ON GASTRIC SECRETION IN THE DOG
THE EFFECT OF OLIVE OIL AND OF COD LIVER OIL ON GASTRIC SECRETION IN THE DOG

 

[rei]

what could be healthier than passing undigested food into the colon??

 

[meatbag]

what could be healthier than passing undigested food into the colon??

Yeah its true, codliver oil and fish oil are still super popular in the fitness world and now in the mainstream are being marketed as brain boosting and are being added to milk and baby formula and parents are buying it.
The Great Fish Oil Experiment

"Chan, et al., 1983, found that polyunsaturated fats caused brain swelling and increased blood vessel permeability. In 1988, Chan's group found that DHA and other polyunsaturated fatty acids added to cultured cells from the cerebral cortex produced free radicals and stimulated production of malondialdehyde and lactate, and inhibited the uptake of glutamic acid, which suggests that they would contribute to prolonged excitation of the nerves (Yu, et al., 1986). In brain slices, the polyunsaturated fatty acids caused the production of free radicals and swelling of the tissue, and the saturated fatty acids didn't (Chan and Fishman, 1980). The PUFA inhibited the respiration of mitochondria in brain cells (Hillered and Chan, 1988), and at a higher concentration, caused them to swell (Hillered and Chan, 1989), but saturated fatty acids didn't produce edema. Free radical activity was shown to cause the liberation of free fatty acids from the cellular structure (Chan, et al., 1982, 1984). The activation of lipases by free radicals and lipid peroxides, with the loss of potassium from the cells, suggests that excitation can become a self-stimulating process, leading to cellular destruction.
DHA itself, rather than its decomposition products, facilitates excitatory (glutamate) nerve transmission (Nishikawa, et al., 1994), and that excitatory action causes the release of arachidonic acid (Pellerin and Wolfe, 1991)."

 

[Tristan Loscha]

Yeah its true, codliver oil and fish oil are still super popular in the fitness world and now in the mainstream are being marketed as brain boosting and are being added to milk and baby formula and parents are buying it.
The Great Fish Oil Experiment

"Chan, et al., 1983, found that polyunsaturated fats caused brain swelling and increased blood vessel permeability. In 1988, Chan's group found that DHA and other polyunsaturated fatty acids added to cultured cells from the cerebral cortex produced free radicals and stimulated production of malondialdehyde and lactate, and inhibited the uptake of glutamic acid, which suggests that they would contribute to prolonged excitation of the nerves (Yu, et al., 1986). In brain slices, the polyunsaturated fatty acids caused the production of free radicals and swelling of the tissue, and the saturated fatty acids didn't (Chan and Fishman, 1980). The PUFA inhibited the respiration of mitochondria in brain cells (Hillered and Chan, 1988), and at a higher concentration, caused them to swell (Hillered and Chan, 1989), but saturated fatty acids didn't produce edema. Free radical activity was shown to cause the liberation of free fatty acids from the cellular structure (Chan, et al., 1982, 1984). The activation of lipases by free radicals and lipid peroxides, with the loss of potassium from the cells, suggests that excitation can become a self-stimulating process, leading to cellular destruction.
DHA itself, rather than its decomposition products, facilitates excitatory (glutamate) nerve transmission (Nishikawa, et al., 1994), and that excitatory action causes the release of arachidonic acid (Pellerin and Wolfe, 1991)."

Peat cites so many mechanistic studies, but in vitro doesnt cut it imo. These are misunderstood Experiments of the fundamentals of Medicine. The Fatty Acids are almost never free, but incorporated into phospholipids, drastically altering their properties. He is still indebted to proof his assertions; The necessity of Arachidonic Acid and DHA for proper CNS development is well documented for in vivo systems and also Humans. There was much experimentation going on with infants. He even cites one Ratmodel - PUFA depletion + CO study, and they show that survival of the next generation was something like 10 percent compared to controls.

 

[postman]

PUFA bomb and retinol bomb, double whammy

He even cites one Ratmodel - PUFA depletion + CO study, and they show that survival of the next generation was something like 10 percent compared to controls.

What study?

 

[Tristan Loscha]

PUFA bomb and retinol bomb, double whammy


What study?

I tried to look it up on his site, but not sure where; i got the full study. I posted the survival issue here on RPF, via screenshot. Maybe i will search it, but not sure.

 

[meatbag]

Peat cites so many mechanistic studies, but in vitro doesnt cut it imo. These are misunderstood Experiments of the fundamentals of Medicine. The Fatty Acids are almost never free, but incorporated into phospholipids, drastically altering their properties. He is still indebted to proof his assertions; The necessity of Arachidonic Acid and DHA for proper CNS development is well documented for in vivo systems and also Humans. There was much experimentation going on with infants. He even cites one Ratmodel - PUFA depletion + CO study, and they show that survival of the next generation was something like 10 percent compared to controls.

There are plenty of in vivo studies;

Higher Omega-3/omega-6 Ratio May Damage The Brain Irreversibly

PUFA Cause Fatal Swelling Seen In Brain Infections; SFA Are Harmless

Lipids. 1996 Aug;31(8):829-37. Effect of dietary n-9 eicosatrienoic acid on the fatty acid composition of plasma lipid fractions and tissue phospholipids. Cleland LG, Neumann MA, Gibson RA, Hamazaki T, Akimoto K, James MJ.

Br J Nutr. 2003 Oct;90(4):777-86. Fish-oil supplementation reduces stimulation of plasma glucose fluxes during exercise in untrained males. Delarue J, Labarthe F, Cohen R.

Eur J Clin Nutr. 2003 Jun;57(6):793-800. Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction. Grundt H, Nilsen DW, Mansoor MA, Nordoy A.

Effects of fish oil and corn oil diets on prostaglandin-dependent and myelopoiesis-associated immune suppressor mechanisms of mice bearing metastatic Lewis lung carcinoma tumors. Young MR, Young ME. Department of Research Services, Edward J. Hines, Jr. "The fish oil diet increased the frequency of myeloid progenitor cells in normal mice and in mice bearing small or large tumors. Concurrently, the fish oil diet stimulated the appearance of bone marrow-derived suppressor cells. When administered after the establishment of palpable primary tumors, a fish oil diet also increased the formation of pulmonary lung nodules." "These data show that a fish oil diet can minimize the immune suppression in tumor bearers when suppression is mediated by PGE2-producing suppressor cells, but can also induce myelopoietic stimulation leading to the appearance of bone marrow-derived suppressor cells and increased tumor metastasis."

Atherosclerosis. 2001 Mar;155(1):9-18. Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. Song JH, Miyazawa T.
Neurochem Res. 1995 Dec;20(12):1417-27.

J Nutr. 2000 Dec;130(12):3028-33. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. Song JH, Fujimoto K, Miyazawa T.

Atherosclerosis. 2001 Mar;155(1):9-18. Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. Song JH, Miyazawa T.

Clin Exp Allergy. 2004 Feb;34(2):194-200. Maternal breast milk long-chain n-3 fatty acids are associated with increased risk of atopy in breastfed infants. Stoney RM, Woods RK, Hosking CS, Hill DJ, Abramson MJ, Thien FC.

Free Radic Res. 2001 Apr;34(4):427-35. Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. Umegaki K, Hashimoto M, Yamasaki H, Fujii Y, Yoshimura M, Sugisawa A, Shinozuka K.

 

[Tristan Loscha]

There are plenty of in vivo studies;

Higher Omega-3/omega-6 Ratio May Damage The Brain Irreversibly

PUFA Cause Fatal Swelling Seen In Brain Infections; SFA Are Harmless

Lipids. 1996 Aug;31(8):829-37. Effect of dietary n-9 eicosatrienoic acid on the fatty acid composition of plasma lipid fractions and tissue phospholipids. Cleland LG, Neumann MA, Gibson RA, Hamazaki T, Akimoto K, James MJ.

Br J Nutr. 2003 Oct;90(4):777-86. Fish-oil supplementation reduces stimulation of plasma glucose fluxes during exercise in untrained males. Delarue J, Labarthe F, Cohen R.

Eur J Clin Nutr. 2003 Jun;57(6):793-800. Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction. Grundt H, Nilsen DW, Mansoor MA, Nordoy A.

Effects of fish oil and corn oil diets on prostaglandin-dependent and myelopoiesis-associated immune suppressor mechanisms of mice bearing metastatic Lewis lung carcinoma tumors. Young MR, Young ME. Department of Research Services, Edward J. Hines, Jr. "The fish oil diet increased the frequency of myeloid progenitor cells in normal mice and in mice bearing small or large tumors. Concurrently, the fish oil diet stimulated the appearance of bone marrow-derived suppressor cells. When administered after the establishment of palpable primary tumors, a fish oil diet also increased the formation of pulmonary lung nodules." "These data show that a fish oil diet can minimize the immune suppression in tumor bearers when suppression is mediated by PGE2-producing suppressor cells, but can also induce myelopoietic stimulation leading to the appearance of bone marrow-derived suppressor cells and increased tumor metastasis."

Atherosclerosis. 2001 Mar;155(1):9-18. Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. Song JH, Miyazawa T.
Neurochem Res. 1995 Dec;20(12):1417-27.

J Nutr. 2000 Dec;130(12):3028-33. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. Song JH, Fujimoto K, Miyazawa T.

Atherosclerosis. 2001 Mar;155(1):9-18. Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. Song JH, Miyazawa T.

Clin Exp Allergy. 2004 Feb;34(2):194-200. Maternal breast milk long-chain n-3 fatty acids are associated with increased risk of atopy in breastfed infants. Stoney RM, Woods RK, Hosking CS, Hill DJ, Abramson MJ, Thien FC.

Free Radic Res. 2001 Apr;34(4):427-35. Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. Umegaki K, Hashimoto M, Yamasaki H, Fujii Y, Yoshimura M, Sugisawa A, Shinozuka K.

To me, all these studies are merely pointing out that these Fatty Acids/Triglycerides are in need of protection, and being a serious liability, like Iron or Calcium. It is a worthy Consensus that PUFA are physiologic, and Peat just points out that PUFA are delicate and in excess quite harmful. The notion of PUFA as mere poisons is not supported by his own reasoning or proofing.