Cod Liver oil and LPS

[salvio]

Cod Liver oil can reduce LPS adsorbition:

"Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis"

Abstract​

In a controlled trial 40 healthy persons (20 men and 20 women) were tested before and after a daily supplement with 25 ml cod liver oil for 8 weeks. The diet increased the eicosapentaenoic acid (20:5 n-3) content in serum and monocytes four- to five-fold whereas the arachidonic acid (20:4 n-6) content decreased 10-20% in both serum and monocytes. Stimulation of blood with a low concentration of lipopolysaccharides (LPS) revealed a 40% suppression of LPS-induced thromboplastin synthesis in the monocytes after 8 weeks of CLO intake. In the same LPS stimulation system, men were found to generate significantly more thromboxane B2 than women (4.9 ng ml-1 versus 3.4 ng ml-1). After the CLO supplementation for 8 weeks the thromboxane B2 was reduced by a mean of 70% in women and 60% in men. Factor VII and fibrinogen appeared to be unaltered by CLO intake. Determination of whole blood clot lysis time and tissue plasminogen activator (t-PA) did not indicate any significant influence of n-3 fatty acids on fibrinolysis.

Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis - PubMed

In a controlled trial 40 healthy persons (20 men and 20 women) were tested before and after a daily supplement with 25 ml cod liver oil for 8 weeks. The diet increased the eicosapentaenoic acid (20:5 n-3) content in serum and monocytes four- to five-fold whereas the arachidonic acid (20:4 n-6)...

pubmed.ncbi.nlm.nih.gov

Is so bad to use it for a short period of time until leaky gut sindrome is healed?

 

[Dave Clark]

Why use any PUFAs when there are other things that can help:

Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes

Zinc carnosine (ZnC) is a health food product claimed to possess health‐promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited.To examine the effect of ZnC on various models of gut ...

www.ncbi.nlm.nih.gov

7 Science-Backed Zinc Carnosine Benefits For Gut Health

Zinc Carnosine is one of the most important supplements you can take to heal your gut. Learn about what it is + the 7 zinc carnosine benefits for gut health|Zinc Carnosine is one of the most important supplements you can take to heal your gut. Learn about what it is + the 7 zinc carnosine...

store.happymammoth.com

 

[salvio]

But is zinc or carnosine to heal it?

 

[salvio]

If you've (all of you) have more suggestions, you're welcome.

 

[Dave Clark]

But is zinc or carnosine to heal it?

It is the combination of zinc and carnosine in the compound that keeps them in the digestive tract to do the healing. Taking either zinc or carnosine individually will cause a different absorption and not stay in the gut to heal the lining. A good deal on this compound with no junk additives: Swanson Ultra Zinc Carnosine - Featuring PepZinGI 60 Caps - Swanson Health Products

 

[salvio]

It is the combination of zinc and carnosine in the compound that keeps them in the digestive tract to do the healing. Taking either zinc or carnosine individually will cause a different absorption and not stay in the gut to heal the lining. A good deal on this compound with no junk additives: Swanson Ultra Zinc Carnosine - Featuring PepZinGI 60 Caps - Swanson Health Products

Oh good thanks. More suggestions?

 

[Rasaari]

It wasn´t about lps absorption, rather the stimulation of blood with lps, and that having lesser thromboplastin synthesis. All fats that absorb from the chylomicrons take lps with them, most studies just test the easy LBP (lipopolysachharide binding protein) which increases with saturated fat, because the immune system is properly neutralizing it. With PUFA lps lingers in the blood and has to be transported via different means, such as hdl. Medium chain triglycerides absorb directly from the portal vein quickly and can avoid binding to lps.

 

[salvio]

It wasn´t about lps absorption, rather the stimulation of blood with lps, and that having lesser thromboplastin synthesis. All fats that absorb from the chylomicrons take lps with them, most studies just test the easy LBP (lipopolysachharide binding protein) which increases with saturated fat, because the immune system is properly neutralizing it. With PUFA lps lingers in the blood and has to be transported via different means, such as hdl. Medium chain triglycerides absorb directly from the portal vein quickly and can avoid binding to lps.

Any studies about?

 

[Rasaari]

Any studies about?

Heres one study, I cant get the full version to open on sci-hub...

Endotoxemia is modulated by quantity and quality of dietary fat in older adults - PubMed

Our results, together with those obtained in a previous study, support the concept that the consumption of the Med Diet, in contrast to a low-fat PUFA diet, constitutes a more suitable dietary lifestyle for preventing the development of atherosclerosis in a population at risk, such as older adults.

pubmed.ncbi.nlm.nih.gov

Results: In the fasting state, we observed lower LPS plasma levels after the consumption of the CHO-PUFA diet (P=0.046) in comparison with the consumption of the Med and SFA-rich diets. In the postprandial measurements, we observed a statistically significant increase in plasma levels of LPS (P=0.044) and a decrease in LBP (P=0.003) after the intake of the CHO-PUFA meal, whereas no postprandial changes were observed after the ingestion of the Med and SFA-rich meals.

Heres an interesting thread on this issue Saturated Fat (palmitate) Does NOT Activate TLR4