raypeatclips
Member
- Joined
- Jul 8, 2016
- Messages
- 2,555
Nothing particularly new in the Peat sphere here but found a nice little study to add to the forum when I was researching alternative antihistamines.
Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium ... - PubMed - NCBI
Allergy. 2011 Mar;66(3):341-50. doi: 10.1111/j.1398-9995.2010.02482.x. Epub 2010 Sep 7.
Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levels.
Strider JW1, Masterson CG, Durham PL.
"
CONCLUSIONS:
Results from this study provide the first evidence of a unique regulatory mechanism by which CO₂ inhibits mast cell degranulation and histamine release by repressing stimulated increases in intracellular calcium. Thus, our data provide a plausible explanation for the reported therapeutic benefit of noninhaled intranasal delivery of 100% CO₂ to treat allergic rhinitis."
Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium ... - PubMed - NCBI
Allergy. 2011 Mar;66(3):341-50. doi: 10.1111/j.1398-9995.2010.02482.x. Epub 2010 Sep 7.
Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levels.
Strider JW1, Masterson CG, Durham PL.
"
CONCLUSIONS:
Results from this study provide the first evidence of a unique regulatory mechanism by which CO₂ inhibits mast cell degranulation and histamine release by repressing stimulated increases in intracellular calcium. Thus, our data provide a plausible explanation for the reported therapeutic benefit of noninhaled intranasal delivery of 100% CO₂ to treat allergic rhinitis."
