md_a
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- Aug 31, 2015
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Expression of TGF‐β1 was increased significantly in the diabetic control group. However, eugenol treatment decreases this increased expression.
Results suggest that treatment with eugenol involved amelioration of diabetic nephropathy by decreasing TGF‐β1 expression.
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Clove oil inhibited 97.3% lipid peroxidation of linoleic acid emulsion at 15 μg/mL concentration. However, under the same conditions, the standard antioxidant compounds such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and trolox demonstrated inhibition of 95.4, 99.7, 84.6 and 95.6% on peroxidation of linoleic acid emulsion at 45 μg/mL concentration, respectively. In addition, clove oil had an effective DPPH scavenging, ABTS+ scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, ferric ions (Fe3+) reducing power and ferrous ions (Fe2+) chelating activities.
Antioxidant activity of clove oil – A powerful antioxidant source - ScienceDirect
Losartan may lead to protection of lung fibrosis through other molecular mechanisms such as downregulation of TGF-β1.
Several viral proteins have been reported to modulate TGF-ß1 signaling, which could induce the proliferation of fibroblasts [25]. Pang et al [27] found higher serum concentrations of TGF-ß1 in SARS patients compared to controls for all clinical courses, including initial, peak, remission, and recovery stages [26,27]. During shortterm follow-up, persistent ground glass opacities, reticular opacities, and pathologic fi ndings of fi brosis have been found in some SARS survivors [28,29]. ...
... Willis et al [30] pointed out that TGF-ß1 was necessary but not sufficient to induce the formation of pulmonary fibrosis [30]. In our study, TGF-ß1 levels increased significantly and remained high after treatment in the severe group, coinciding with reports of patients with SARS-CoV infection [23,26]. This phenomenon could well be explained by the existence of imminent pulmonary fibrosis. ...
https://www.researchgate.net/public...dulates_Transforming_Growth_Factor-_Signaling
Results suggest that treatment with eugenol involved amelioration of diabetic nephropathy by decreasing TGF‐β1 expression.
Error - Cookies Turned Off
Clove oil inhibited 97.3% lipid peroxidation of linoleic acid emulsion at 15 μg/mL concentration. However, under the same conditions, the standard antioxidant compounds such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and trolox demonstrated inhibition of 95.4, 99.7, 84.6 and 95.6% on peroxidation of linoleic acid emulsion at 45 μg/mL concentration, respectively. In addition, clove oil had an effective DPPH scavenging, ABTS+ scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, ferric ions (Fe3+) reducing power and ferrous ions (Fe2+) chelating activities.
Antioxidant activity of clove oil – A powerful antioxidant source - ScienceDirect
Losartan may lead to protection of lung fibrosis through other molecular mechanisms such as downregulation of TGF-β1.
Several viral proteins have been reported to modulate TGF-ß1 signaling, which could induce the proliferation of fibroblasts [25]. Pang et al [27] found higher serum concentrations of TGF-ß1 in SARS patients compared to controls for all clinical courses, including initial, peak, remission, and recovery stages [26,27]. During shortterm follow-up, persistent ground glass opacities, reticular opacities, and pathologic fi ndings of fi brosis have been found in some SARS survivors [28,29]. ...
... Willis et al [30] pointed out that TGF-ß1 was necessary but not sufficient to induce the formation of pulmonary fibrosis [30]. In our study, TGF-ß1 levels increased significantly and remained high after treatment in the severe group, coinciding with reports of patients with SARS-CoV infection [23,26]. This phenomenon could well be explained by the existence of imminent pulmonary fibrosis. ...
https://www.researchgate.net/public...dulates_Transforming_Growth_Factor-_Signaling
