Cistanche / Echinachoside restores Tyrosine hydroxilase expression to normal in Parkinson's

[Mauritio]

It has been established before that cistanche helps with Parkinson's and has a pro-dopamine effect.

This study looked a bit deeper into the mechanism of it.
In my opinion most noteworthy is the almost complete recovery of Tyrosine hydroxilase in tje sibstabtia nigra of Parkinson's mice.

They show that Echinachoside, the main glycoside of cistanche, has anti-inflammatory actions and i suspect that is the way it rescues the dopaminergic neurons and TH expression.

Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson’s Disease Model

Echinacoside (ECH), the major active constituent of Cistanche deserticola, was found to exert neuroprotection through neurotrophic and anti-inflammatory functions in Parkinson’s disease (PD) models. However, a clear intermediate molecule or pathway ...

www.ncbi.nlm.nih.gov

 

[Mauritio]

Here's a recent paper on Echinachoside's benefits for neurodegenerative diseases.

Therapeutic Potential and Molecular Mechanisms of Echinacoside in Neurodegenerative Diseases - PubMed

Echinacoside (ECH) is a natural phenylethanoid glycoside (PhG) in <i>Cistanche tubulosa</i>. A large number of studies have shown that ECH has very promising potential in the inhibition of neurodegenerative disease progression. Experimental studies strongly suggest that ECH exhibits a variety of...

pubmed.ncbi.nlm.nih.gov