- May 4, 2019
I will order some NDT now. Also will look for some pregnenolone. The question is, do I even have low adrenals. My DHEA is high, out of range high on every blood test. My morning Cortisol is normal/high. Waiting on more tests on this and my Aldosterone we don't know yet but have bloods on Aldosterone & Renin next week. Would Pregnenoloe/Progesterone still be a good idea of my adrenals are in fact hyper, rather than hypo?
Gut issues was my next port of call. Considering getting some of the tests listed here Test Kits such as the organic acids or stool test. Or is there a better option? I'm in the UK.
Yeah I would say it's still worth experimenting with. Elevated DHEA is likely to help oppose high cortisol (from stress).
Progesterone especially is profoundly soothing and anti-stress, it can be very therapeutic to break a vicious stress/inflammatory cycle. Here's a source of Progest-E in the UK Progest E | 34ml - Kenogen . It's Ray Peat approved because he patented the formula himself lol.
Ideally you would want to identify the underlying issues of what is causing your adrenals to pump out cortisol/DHEA. Could be SIBO, gut dysbiosis, increased intestinal permeability. Could be hypothyroidism. Or both. I don't know much about those tests, lactulose breath test is typically used to test for SIBO.
Quotes from Ray:
"Increasingly, in both sexes, it appears that DHEA may rise during stress as a result of a deficiency of thyroid, progesterone, and pregnenolone."
"In experiments, progesterone was found to be the basic hormone of adaptation and of resistance to stress. The adrenal glands use it to produce their anti-stress hormones, and when there is enough progesterone, they don't have to produce the potentially harmful cortisone. In a progesterone deficiency, we produce too much cortisone, and excessive cortisone causes osteoporosis, aging of the skin, damage to brain cells, and the accumulation of fat, especially on the back and abdomen."
"In a healthy young person or animal, taking even a large dose of pregnenolone has no hormone-like or drug-like action at all. It is unique in this way. But if the animal or person is under stress, and producing more cortisone than usual, taking pregnenolone causes the cortisone to come down to the normal level."