Chronic Benzodiazepine Use Linked To Dementia And Alzheimers

haidut

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Given how popular the benzos are among the mental health professionals, I wonder if the recent epidemic of various dementias including AD is at least partially due to overusing those drugs. For those that do need an anti-anxiety drug, niacinamide works just like a benzo but protects against (and maybe even reverses) Alzheimers. There is a clinical trial going on with 3g niacinamide daily for AD patients.

http://www.bbc.com/news/health-29127726

http://clinicaltrials.gov/show/NCT00580931
 

jayegray

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Given how popular the benzos are among the mental health professionals, I wonder if the recent epidemic of various dementias including AD is at least partially due to overusing those drugs. For those that do need an anti-anxiety drug, niacinamide works just like a benzo but protects against (and maybe even reverses) Alzheimers. There is a clinical trial going on with 3g niacinamide daily for AD patients.

Anxiety and sleeping pills 'linked to dementia' - BBC News

Safety Study of Nicotinamide to Treat Alzheimer's Disease - Full Text View - ClinicalTrials.gov
I have taken up to 5g in one day of niacinamide and only noticed increased anxiety and felt very stressed but when I take an actual benzodiazepine I feel very calm and relaxed. Would you know why this is?
 

TubZy

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So why does benzos cause AD and dementia ? Is it from excessive GABA levels?
 

haidut

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I have taken up to 5g in one day of niacinamide and only noticed increased anxiety and felt very stressed but when I take an actual benzodiazepine I feel very calm and relaxed. Would you know why this is?

Not sure why you would take such bigger dose. The benzo qualities of niainamide are in the 500mg - 2,000mg range. Even at these doses niacinamide potent effects on metabolism, blood sugar, FFA, etc which other benzos don't. Just because niacinamide can act like a benzo does not mean it is the only thing it can do. So, I would always use niacinamide with food and if used of anxiety 1,000mg - 1,500mg daily is probably plenty. As you can see below, other get sedated even in low doses.
Vitamin K2 (MK-4) May Be A Treatment For Rheumatoid Arthritis
 

FredSonoma

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I have people on my family on benzos and they exhibit the most strange behavior. Very confusing mix of being very heartless, but needy. Niacinamide certainly helps but I don't think it is a full solution.
 

haidut

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I have people on my family on benzos and they exhibit the most strange behavior. Very confusing mix of being very heartless, but needy. Niacinamide certainly helps but I don't think it is a full solution.

Theanine on its own or in combination with some niacinamide should rival most benzos.
 

Vinero

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Phenibut has to be the worst drug ever. Totally messed up my gut and caused severy anxiety and panic attacks after quiting. Altough it's likely a quality issue. It seems that most if not all phenibut comes from cheap Chinese manufacturers and contains a lot of contaminants. If you want the real stuff you need to import it from Russia, it's actually a prescription drug there and is much higher qualitiy. Like night and day difference. Back in 2012 I think I had a clean batch and it was absolutely euphoric like feeling and relaxation. No gut issues at all. Then all of a sudden all batches felt very "dirty" and not euphoric at all. It caused severe gut irritation and just made me drowsy with an awful anxiety rebound.
 
Last edited:

jayegray

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Not sure why you would take such bigger dose. The benzo qualities of niainamide are in the 500mg - 2,000mg range. Even at these doses niacinamide potent effects on metabolism, blood sugar, FFA, etc which other benzos don't. Just because niacinamide can act like a benzo does not mean it is the only thing it can do. So, I would always use niacinamide with food and if used of anxiety 1,000mg - 1,500mg daily is probably plenty. As you can see below, other get sedated even in low doses.
Vitamin K2 (MK-4) May Be A Treatment For Rheumatoid Arthritis
I have taken up to 5 grams as an experiment, starting at 200mg a day. No noticeable difference up until 1500 mg and then it gives a stress response. Then I went all the way up to 5 grams with the same effects basically. So at no dose did I notice anything like what a benzo does to me. Also I have a tried Theanine at various doses and no positive effect but at higher doses it feels similar to niacinamide.
 

Regina

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I have taken up to 5 grams as an experiment, starting at 200mg a day. No noticeable difference up until 1500 mg and then it gives a stress response. Then I went all the way up to 5 grams with the same effects basically. So at no dose did I notice anything like what a benzo does to me. Also I have a tried Theanine at various doses and no positive effect but at higher doses it feels similar to niacinamide.
I'm weird in that I do not feel the difference in many supplements. I don't notice any difference on niacinamide or theanine but I am aware of niacinamide benefits. I've only taken 1500mg in a given day.
 

jayegray

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I'm weird in that I do not feel the difference in many supplements. I don't notice any difference on niacinamide or theanine but I am aware of niacinamide benefits. I've only taken 1500mg in a given day.
It is always interesting when a chemical is supposed to do one thing but in some people it does nothing or has the complete opposite effect.
 
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DaveFoster

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I only experienced the benzo effect from niacinamide the first time I tried it and after extensive breaks. Tolerance develops quickly, but when you get the initial wave of relaxation, it's awesome.
 
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