Chris Masterjohn Warns About A,D & C For COVID19

RealNeat

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Here are some excerpts. To me it seems very reductionist and like incentive for people to buy his article.

"For example, the coronavirus gets into our cells by hijacking a substance known as “ACE2” whose normal role is to keep our blood pressure from getting too high and to keep our lungs and heart healthy. Vitamins A and D are normally incredibly important to our immune systems. They help us make antibodies and other virus-busting weaponry. And they support our blood pressure and the health of our lungs and heart by helping us make more ACE2. "

"Vitamins A and D are good for our lungs, good for our heart, and they support our immune system. Yet, by increasing the amount of ACE2 that the coronavirus can hijack in order to get inside our cells, supplementing with them may actually make us more vulnerable to infection."

"However, there aren’t any studies testing vitamin C against any of the coronaviruses. No one in the study of vitamin C injections was suffering from SARS, the new coronavirus’s evil twin. Studies show conflicting effects of vitamin C on interferon: in some cases it increases it; in others, it decreases it. Therefore, it is difficult to predict whether vitamin C would make things better or worse during the inflammatory destruction of the lungs that happens with SARS and the new coronavirus."

He's apparently charging for this info. Not good juju to make money from in my opinion.
https://chris-masterjohn-phd.myshop...food-and-supplement-guide-for-the-coronavirus
Here's the whole thing if you want to buy it
https://chris-masterjohn-phd.myshop...food-and-supplement-guide-for-the-coronavirus
The Food and Supplement Guide for the Coronavirus
 

InChristAlone

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Here are some excerpts. To me it seems very reductionist and like incentive for people to buy his article.

"For example, the coronavirus gets into our cells by hijacking a substance known as “ACE2” whose normal role is to keep our blood pressure from getting too high and to keep our lungs and heart healthy. Vitamins A and D are normally incredibly important to our immune systems. They help us make antibodies and other virus-busting weaponry. And they support our blood pressure and the health of our lungs and heart by helping us make more ACE2. "

"Vitamins A and D are good for our lungs, good for our heart, and they support our immune system. Yet, by increasing the amount of ACE2 that the coronavirus can hijack in order to get inside our cells, supplementing with them may actually make us more vulnerable to infection."

"However, there aren’t any studies testing vitamin C against any of the coronaviruses. No one in the study of vitamin C injections was suffering from SARS, the new coronavirus’s evil twin. Studies show conflicting effects of vitamin C on interferon: in some cases it increases it; in others, it decreases it. Therefore, it is difficult to predict whether vitamin C would make things better or worse during the inflammatory destruction of the lungs that happens with SARS and the new coronavirus."

He's apparently charging for this info. Not good juju to make money from in my opinion.
Here's the whole thing if you want to buy it
The Food and Supplement Guide for the Coronavirus
Thats interesting because Peat said ACE2 is higher in young people and that's why they aren't dieing of a cold virus.
 

LLight

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Or maybe ACE2 is not the infection pathway:

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

sandeep chakraborty on Twitter

Which is interesting because:
Basigin - Wikipedia

"Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene.[4][5][6] This protein is a determinant for the Ok blood group system. Basigin has been shown to be an essential receptor on red blood cells for the human malaria parasite, Plasmodium falciparum."

Chloroquine is a drug against malaria.
 
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Noodlz2

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Thats interesting because Peat said ACE2 is higher in young people and that's why they aren't dieing of a cold virus.

To add context, Peat said:

-Angiotensin excess causes the negative symptoms we associate with the virus - dry cough, fever, high blood pressure, etc.
-Angiotensin excess is caused by ACE2, the enzyme that deactivates Angiotensin, not being available to do its job.
-ACE2 is not available to do it's job because the virus binds to it.

So Chris M says ACE2 is bad because it gives the virus a place to bind to. He seems to be missing the point that without ACE2, Angiotensin excess would cause problems, so we obviously need ACE2 in some amount. So the virus always will have a place to bind to (unless we are deficient in ACE2, in which case we're already in a bad place). Whether or not the virus causes bad symptoms probably depends on how much ACE2 we have. With less ACE2, a little bit of the virus will incapacitate all of the ACE2, and we're susceptible to angiotensin overload. On the other end of the spectrum, with a lot of ACE2, it will take a lot of the virus to incapacitate us. So, on the surface, it seems that excess ACE2 would be protective against the virus' bad effects.

This is from around the 15m mark in Ray's interview with Patrick on March 16 btw.
Dr. Ray Peat - Understanding the Coronavirus, Why Wuhan Was So Affected and More! - March 16, 2020 | One Radio Network
 
OP
RealNeat

RealNeat

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I just want o be fair here and say that I haven't read his full article. If someone ends up paying for it and reading the whole thing, it would be interesting to see his full context.
 

Diokine

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I'm so glad that Dr. Chris Masterjohn, PhD, is willing to debunk these potentially dangerous alternative treatments. It's true the results of studies examining the effect of intravenous vitamin C in coronavirus infection, specifically SARS-Cov2, aren't yet available.

However!

The mechanism of lung injury in cases like these is strikingly similar to sepsis-related ARDS, and in some cases may be indistinguishable. In fact the pattern of injury in the lungs is decently elucidated and is related to substantial oxidative injury related to neutrophil respiratory bursts generating massive amounts of ROS including hydrogen peroxide. This is remarkably similar to poisoning and injury induced by paraquat poisoning, and in these cases severely reduced levels of glutathione are found. Intravenous ascorbate and nebulized glutathione is one effective treatment of paraquat poisoning.

At any rate, people who know what they are talking about seem to think intravenous vitamin C is effective.

Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia


Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome
In conclusion, we report here the first use of vitamin C as an interventional drug to attenuate lung injury produced by viral infection. The patient described here was discharged home 12 d following hospitalization, requiring no oxygen therapy. Follow-up exam at 1 mo following the patient’s initial hospitalization revealed her to have completely recovered.
 
OP
RealNeat

RealNeat

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I'm so glad that Dr. Chris Masterjohn, PhD, is willing to debunk these potentially dangerous alternative treatments. It's true the results of studies examining the effect of intravenous vitamin C in coronavirus infection, specifically SARS-Cov2, aren't yet available.

However!

The mechanism of lung injury in cases like these is strikingly similar to sepsis-related ARDS, and in some cases may be indistinguishable. In fact the pattern of injury in the lungs is decently elucidated and is related to substantial oxidative injury related to neutrophil respiratory bursts generating massive amounts of ROS including hydrogen peroxide. This is remarkably similar to poisoning and injury induced by paraquat poisoning, and in these cases severely reduced levels of glutathione are found. Intravenous ascorbate and nebulized glutathione is one effective treatment of paraquat poisoning.

At any rate, people who know what they are talking about seem to think intravenous vitamin C is effective.

Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia


Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome

Idk if "willing to debunk" is the right statement. If this information could save many lives it should be free. Plus when observing the experimental drugs like cholorquine and remdesivir and their side effects those imo become lumped into the "potentially dangerous alternative treatment"category too. I'd choose to emphasize D from Sun and A from food personally knowing that the mechanism of action those nutrients encourage are far more deeply rooted in our biology than synthetic pharma substances.

Japan's drug victims lose fight for compensation
 
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Edind9

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The virus activates the angiotensin receptor, so the receptor blockers are protective—losartan, telmisartan, etc. Progesterone is a natural inhibitor of that receptor. Also the usual antiinflammatory things, aspirin, eggnog, orange juice would be helpful.


this from ray peat
 

lampofred

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So Chris M says ACE2 is bad because it gives the virus a place to bind to. He seems to be missing the point that without ACE2, Angiotensin excess would cause problems, so we obviously need ACE2 in some amount. So the virus always will have a place to bind to (unless we are deficient in ACE2, in which case we're already in a bad place). Whether or not the virus causes bad symptoms probably depends on how much ACE2 we have. With less ACE2, a little bit of the virus will incapacitate all of the ACE2, and we're susceptible to angiotensin overload. On the other end of the spectrum, with a lot of ACE2, it will take a lot of the virus to incapacitate us. So, on the surface, it seems that excess ACE2 would be protective against the virus' bad effects.

Good reasoning imo. Explains why young people who have more ACE2 are less susceptible to the virus.
 

ddjd

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Here are some excerpts. To me it seems very reductionist and like incentive for people to buy his article.

"For example, the coronavirus gets into our cells by hijacking a substance known as “ACE2” whose normal role is to keep our blood pressure from getting too high and to keep our lungs and heart healthy. Vitamins A and D are normally incredibly important to our immune systems. They help us make antibodies and other virus-busting weaponry. And they support our blood pressure and the health of our lungs and heart by helping us make more ACE2. "

"Vitamins A and D are good for our lungs, good for our heart, and they support our immune system. Yet, by increasing the amount of ACE2 that the coronavirus can hijack in order to get inside our cells, supplementing with them may actually make us more vulnerable to infection."

"However, there aren’t any studies testing vitamin C against any of the coronaviruses. No one in the study of vitamin C injections was suffering from SARS, the new coronavirus’s evil twin. Studies show conflicting effects of vitamin C on interferon: in some cases it increases it; in others, it decreases it. Therefore, it is difficult to predict whether vitamin C would make things better or worse during the inflammatory destruction of the lungs that happens with SARS and the new coronavirus."

He's apparently charging for this info. Not good juju to make money from in my opinion.
Here's the whole thing if you want to buy it
The Food and Supplement Guide for the Coronavirus
Kevin Bass, MS on Twitter

From @ChrisMasterjohn's $9.99 guide to coronavirus

Recommendation: Supplement with copper.
Evidence: Coronavirus does not survive for very long on brass.

Apparently Chris "lost a ton of sleep" to write this guide

What a world Kevin Bass, MS on Twitter
 

boris

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„The guide costs $9.99. That's just a tiny slice of the money this might save you just by avoiding a pricey supplement that probably doesn't work.

By the way, you can also get the report for free if you pre-order a copy of my Vitamins and Minerals 101 book. “

Cashing in on the panic. What a scum.
 

yoshiesque

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I bought his COVID guide. He basically states following as protective:

Elderberry
Nutritional Zinc
Ionic Zinc Lozenge or Spray
Copper

Optional ones to add:
Garlic, Echinacea, Vit C 150mg, NAC.
Avoid high doses vit A, D, Calcium, Monolaurin.
He did state to avoid some things coz they put more strain on lungs. That part kinda makes sense.
 

yerrag

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-Angiotensin excess causes the negative symptoms we associate with the virus - dry cough, fever, high blood pressure, etc.
-Angiotensin excess is caused by ACE2, the enzyme that deactivates Angiotensin, not being available to do its job.
There seems to be a typo here. Doesn't make sense.
 
J

jb116

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I'm extremely disappointed in Chris.
There seems to be a typo here. Doesn't make sense.
There is no typo as far as I can see. What are you seeing that you feel is wrong? It might be the way the sentence was phrased
 

yerrag

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I'm extremely disappointed in Chris.

There is no typo as far as I can see. What are you seeing that you feel is wrong? It might be the way the sentence was phrased
Perhaps how it's phrased.

Angiotensin excess is caused by ACE2, and yet ACE2 is the enzyme that deactivates angiotensin? Contradictory. So, not typo. Ideas stated cancel each other out.
 

tara

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Thats interesting because Peat said ACE2 is higher in young people and that's why they aren't dieing of a cold virus.
Hardly anyone is dying of a cold virus, either rhinoviruses or corona.
It's CoVID-19/SARS-CoV2 that has been lethally epidemic this year.
-Angiotensin excess is caused by ACE2, the enzyme that deactivates Angiotensin, not being available to do its job.
Angiotensin excess is caused by ACE2, and yet ACE2 is the enzyme that deactivates angiotensin? Contradictory. So, not typo. Ideas stated cancel each other out.
I had to reread that one too. But it's consistent, if you read to the end of the sentence - just the intervening clause might have thrown us off.
To paraphrase:
-Angiotensin excess is caused by ACE2 not being available to do its job. ACE2 is the enzyme that deactivates Angiotensin,
 
J

jb116

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Perhaps how it's phrased.

Angiotensin excess is caused by ACE2, and yet ACE2 is the enzyme that deactivates angiotensin? Contradictory. So, not typo. Ideas stated cancel each other out.

Hardly anyone is dying of a cold virus, either rhinoviruses or corona.
It's CoVID-19/SARS-CoV2 that has been lethally epidemic this year.


I had to reread that one too. But it's consistent, if you read to the end of the sentence - just the intervening clause might have thrown us off.
To paraphrase:

Yes, exactly.
If it simply read when Ace 2 can't do its job then there is excess Angiotensin, would be easier to follow.
 

yerrag

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Hardly anyone is dying of a cold virus, either rhinoviruses or corona.
It's CoVID-19/SARS-CoV2 that has been lethally epidemic this year.


I had to reread that one too. But it's consistent, if you read to the end of the sentence - just the intervening clause might have thrown us off.
To paraphrase:

Yes, exactly.
If it simply read when Ace 2 can't do its job then there is excess Angiotensin, would be easier to follow.

Thanks. I just couldn't connect the dots there. Stuck in a loop for a while.
 

yerrag

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This wikipedia entry on ACE2 seems very helpful. It has mention of the virus as an entry point to the cell. Towards the last part, makes mention of ACE inhibitors upregulating ACE2:

Angiotensin-converting enzyme 2 - Wikipedia

Treatment with angiotensin-converting enzyme (ACE) inhibitors results in an upregulation of ACE2,[23] which is expressed by epithelial cells of the lung, intestine, kidney, and blood vessels. This increased expression of ACE2 may facilitate infection with SARS-CoV or SARS-CoV-2. Hence, patients with diabetes or hypertension being treated with ACE inhibitors may be at increased risk of COVID-19 infection.[22]
 
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Or maybe ACE2 is not the infection pathway:

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

sandeep chakraborty on Twitter

Which is interesting because:
Basigin - Wikipedia

"Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene.[4][5][6] This protein is a determinant for the Ok blood group system. Basigin has been shown to be an essential receptor on red blood cells for the human malaria parasite, Plasmodium falciparum."

Chloroquine is a drug against malaria.


good thinking.
That is one good mechanistic target for the reported efficacy of Chloroquine.

Chloroquine isnt safe for consumption it seems.
Capacity for unclearable build-up in affected Cells.
A lot of CNS-sides.

Mefloquine,a related compound,is seen as neurotoxic,wasnt always this way.

I have an anthology of career-Psychiatrists with U.S. military as employer who were openly writing
that military-duty associated PTSD was coming from Mefloquine use.

How do they know?They administer it for Malaria-Phophylaxis,(only known Agent capable of
giving longer-term future protection,via recirculation and lack of clearance+.)
and in the night or the day after intake,personnel starts to act out with psychotic-like delusions
and confusion.

Those that are afflicted are thought of having CNS-uptake of the drug
and that the presence causes direct toxicity,inducing vague brainstem-pathology.

Cholorquine is a closely related compound,maybe it should be avoided.
Liponavir+Ritonavir fixed combination seems a lot safer.
 
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