Tarmander
Member
- Joined
- Apr 30, 2015
- Messages
- 3,772
Couple people are commenting on facebook on a recent post at the end of November from Chris Masterjohn on Facebook.
Lots of theories around this. Veganism, too much Vit A, etc.
Here is the quote from his post:
"I went in for an MRI last night. I was nervous AF about getting injected with gadolinium contrast and you can probably tell the anxiety level is way higher in my before picture versus in the post-MRI beer pic.
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I’m investigating an abnormal gait that has crept up on me three times now. The first time was while I was on terbinafine in 2017 for a fungal infection. The second was in January or so of this year after I’d switched my main carbs from beans and veggies to butternut squash. This last time seemed to come up after I started tanning, which helps my eczema whenever it starts creeping up.
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The gait issue feels like I have to pick my legs up too high to move. My girlfriend noticed my left leg dragging too.
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Every time it happens I adjust a few things and it goes away. The terbinafine also caused severe twitching, which I solved by getting enough potassium and avoiding alcohol and acids. As it subsided it settled into a fuzzy paresthesia in my cheeks that got better and better over time. The last bout of twitching is highly effectively managed with strategies targeting acid-base balance and glutamate (currently emphasizing beta-alanine and B6). The gait issue seemed to resolve in response to ensuring adequate B vitamins across the board.
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By the time I went to the neurologist the gait issue was 95% gone, but she thought me having a witness to the leg dragging compelling enough to do an MRI and EMG.
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If I find anything interesting I’ll be using it to probe whether I have any genetics that could offer a unified explanation for why veganism and terbinafine both seem to have caused neurological problems for me. Notably, my cholesterol is always low (currently 140-160), veganism slashed it to 106, and terbinafine works by inhibiting fungal sterol synthesis and is 60% active against human cholesterol synthesis.
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When I have more info I’ll keep you up to date!"
His post is from Nov 26th here: Chris Masterjohn, PhD
Lots of theories around this. Veganism, too much Vit A, etc.
Here is the quote from his post:
"I went in for an MRI last night. I was nervous AF about getting injected with gadolinium contrast and you can probably tell the anxiety level is way higher in my before picture versus in the post-MRI beer pic.
⠀
I’m investigating an abnormal gait that has crept up on me three times now. The first time was while I was on terbinafine in 2017 for a fungal infection. The second was in January or so of this year after I’d switched my main carbs from beans and veggies to butternut squash. This last time seemed to come up after I started tanning, which helps my eczema whenever it starts creeping up.
⠀
The gait issue feels like I have to pick my legs up too high to move. My girlfriend noticed my left leg dragging too.
⠀
Every time it happens I adjust a few things and it goes away. The terbinafine also caused severe twitching, which I solved by getting enough potassium and avoiding alcohol and acids. As it subsided it settled into a fuzzy paresthesia in my cheeks that got better and better over time. The last bout of twitching is highly effectively managed with strategies targeting acid-base balance and glutamate (currently emphasizing beta-alanine and B6). The gait issue seemed to resolve in response to ensuring adequate B vitamins across the board.
⠀
By the time I went to the neurologist the gait issue was 95% gone, but she thought me having a witness to the leg dragging compelling enough to do an MRI and EMG.
⠀
If I find anything interesting I’ll be using it to probe whether I have any genetics that could offer a unified explanation for why veganism and terbinafine both seem to have caused neurological problems for me. Notably, my cholesterol is always low (currently 140-160), veganism slashed it to 106, and terbinafine works by inhibiting fungal sterol synthesis and is 60% active against human cholesterol synthesis.
⠀
When I have more info I’ll keep you up to date!"
His post is from Nov 26th here: Chris Masterjohn, PhD