Chicken Meat ACE-Inhibitors Peptides

SOMO

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Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. - PubMed - NCBI
Four peptides that inhibit angiotensin-converting enzyme (ACE) were separated from the hydorlysate of boneless chicken leg meat digested with artificial gastric juice (pepsin). Two peptides were identified as the peptides encrypted in myosin heavy chain. The peptide P1 (MNVKHWPWMK) corresponds to the amino acid sequence from amino acids 825 to 834 of myosin heavy chain, and the peptide P4 (VTVNPYKWLP) corresponds to the amino acid sequence from amino acids 125 to 135 of myosin heavy chain. They are novel ACE inhibitory peptides derived from chicken, and IC(50) values of P1 and P4 were determined as 228 and 5.5 microM, respectively. Although these values were much larger than 0.022 microM for captopril, a typical synthetic ACE inhibitor, they are comparable to IC(50) values reported for various ACE inhibitory peptides derived from foods. Because the peptide P4 has a relatively low IC(50) value, it is a good starting substance for designing food supplements for hypertensive patients.

Only in the chicken leg meat lol.

Meat is a complex soup of bioactive substances, not just minerals, vitamins and fats.
 
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Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. - PubMed - NCBI


Only in the chicken leg meat lol.

Meat is a complex soup of bioactive substances, not just minerals, vitamins and fats.

Thanks very interesting.

Can we speculate that those peptides are derived from legs because they are related to legs role in body and their activity? It would probably mean that other animal could have similar peptides.

As far studies say yes!

Purification and Identification of Angiotensin Converting Enzyme Inhibitory Peptides From Beef Hydrolysates - PubMed

Sarcoplasmic protein extracts from beef rump (biceps femoris) were hydrolyzed (for 0, 4, 8, 12, and 24 h) with three enzymes or their paired combinations. Ultrafiltration, gel-filtration, and RP-HPLC were used to separate angiotensin converting enzyme (ACE) inhibitory peptides from the hydrolysates. The highest ACE inhibitory activity of enzyme hydrolysates resulted from 4 h incubation with enzymes or their paired combinations. The activities of gel filtrated fractions from these hydrolysates were assayed in vitro, demonstrating that the 3rd peak of enzyme thermolysin+proteinase A hydrolysate had the highest ACE inhibition activity (52.8%). The 3rd peak of this hydrolysate was separated by RP-HPLC into five peaks, of which peak 3 showed 30.1% ACE inhibition activity. Its peptide sequence was determined to be Val-Leu-Ala-Gln-Tyr-Lys. The results suggested that this peptide may be a potent ACE inhibitor which might perhaps be used to develop beef with a bioactive peptide to lower blood pressure.


I would speculate every part of an animal has specific peptides with special role in every particular part. E.g. heart has heart specific peptides. Traditional Chinese medicine doesn't look that unscientific now. Eat heart to manage heart problems. Hmm.
 
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