Chaotropic ions and estrogen have the same nature

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Effect of chaotropic anions on the rate of dissociation of estradiol-receptor protein complexes of mouse uterine cytosol

<<The stability of mouse uterine cytosol receptor-[3H]estradiol complex was evaluated in the presence of neutral salts of the Hoffmeister series. Marked increases in the rate of dissociation of the complex were observed with the more chaotropic anions (SCN−,ClO4-,NO3-, Br−), and the effects of these ions were greater at lower temperatures, where water assumes a more rigid structure. At higher temperatures F− and CH3COO−, which tend to stabilize water structure, led to retardation of the rate of dissociation of the hormone-receptor complex.>>

So anything that destructures water "helps" estradiol "dissociate" from its "receptor" so more estrogen can come in.

Accelerated dissociation of estrogen receptor-ligand complexes by estradiol. Evidence for negative cooperativity of binding

<<The rate of dissociation of 17β-[3H]estradiol that had been previously equilibrated to a low degree of saturation of immature rat uterine cytoplasmic estrogen receptor was shown to increase over 40-fold in the presence of additional ligand.>>

So we see that estradiol does the same thing to estradiol dissociation which chaotropic ions do.

17β-estradiol induces non-genomic effects in renal intercalated cells through the G-protein coupled estrogen receptor 1

<<Physiological concentrations of E2 induced transient increases in the intracellular Ca2+ concentration ([Ca2+]i) in a subpopulation of cells. The [Ca2+]i increases required extracellular Ca2+ and were inhibited by Gd3+. Strikingly, the classical E2 receptor antagonist ICI 182,780 also increased [Ca2+]i, which is inconsistent with the activation of classical E2 receptors.>>

Here we see that a classical "antagonist" of the "estrogen receptor" causes calcium influx just as much as estradiol. This further discounts the meaning of "estrogen receptor". Furthermore, this substance which in some situations can block estrogen's effects, is simply an estradiol molecule with a long chain attached and fluoride (kosmotropic?) atoms at the end of it. The effect of the pure antiestrogen was to inhibit nucleocytoplasmic shuttling of the receptor by blocking its nuclear uptake. [ http://www.ncbi.nlm.nih.gov/pubmed/8126115 ]

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Here is a good explanation of the Hoffmeister series:

hofmeister.gif
 

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