Century-long metabolic decline, not less exercise and/or more eating, causing the obesity epidemic

haidut

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I did a few posts years ago on the alarming findings that the youngest generations are among the most physically active, consume the least amount of calories, yet are the most obese (on average) compared to previous generations going back to at least the 1950s. Those studies did not look at specific reasons, but opined that since the trend also matches the decline in IQ scores, testosterone levels, fertility, lifespan, etc the cause is likely something profoundly systemic that affects all of these variables. One of those studies suggested that it is a decline in metabolism that may be to blame, listing in support the much higher caloric intake recorded among both children and adults in the 1950s. The study even listed commercials from that time period showing medical advertisements to mothers suggesting children eat 4-5 meals daily with plenty of sugar-sweetened soda, ice cream, pastry, etc. The study below supports that hypothesis by demonstrating that adjusted basal metabolic rates (BMR) have declined by double digits over the last three (3) decades and that this is a trend that goes back at least a century. It does not take much acumen to realize that with double digit declines over a 3-decade period, by now our BMR is probably only half of the BMR of people who lived at the turn of the 20th century. What makes the situation worse is that if BMR has declined so much, the current guidelines for "optimal" health - reduced caloric intake and plenty of exercise - are virtually guaranteed to make the situation worse since they will invariably further lower the BMR. If this vicious cycle is not broken, I think the W.H.O. projection that half of adults will be obese/diabetic by 2050 is actually quite optimistic. Oh, and last but not least - what could be causing these declines in BMR? Well, chronic stress aside, that decline in BMR mirrors almost perfectly the curves of PUFA consumption rates in the general population. Namely, as the BMR curve has steadily declined over the last 100 years the PUFA consumption rate curve has steadily moved upwards over time. Unless this trend of ever-increasing PUFA consumption is interrupted, I don't see the decline of BMR flattening (let alone reversing) any time soon.

Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure - Nature Metabolism
Obesity Epidemic Linked to Unexpected Factor: New Study

"...A new study published in Nature Metabolism (pdf) has revealed that the basal metabolic rate (BMR) in people in the United States and Europe has decreased over the past three decades, potentially contributing to the growing obesity epidemic in both regions. Basal metabolic rate, or basal energy expenditure, refers to the energy required per unit of time for the body to maintain vital functions such as breathing, blood circulation, and maintaining body temperature. Put simply, BMR is the number of calories the body burns while at rest. BMR is one component in the body’s total energy expenditure. The other is activity expenditure, the number of calories burned during physical activity, such as running or walking. According to the study, which analyzed data from the present day back to the late 1980s from nearly 4,800 adults in Europe and the United States, the adjusted total daily energy expenditure has decreased significantly since the 1990s. The data indicated a decline of approximately 7.7 percent in men and 5.6 percent in women. In terms of adjusted basal energy expenditure, men experienced a drop of 14.7 percent over time, while women’s decline was 2 percent and not deemed significant. However, the authors noted that a larger dataset of BMR measurements of nearly 10,000 adults across 163 studies going back 100 years confirms the decline in both men and women. “The surprising conclusion is we spend less energy when resting now than individuals did 30-40 years ago!” John Speakman, a professor at the Chinese Academy of Sciences in Shenzhen, China, and a lead author of the study, wrote on Twitter. “The magnitude of the effect is sufficient to explain the obesity epidemic.” Speakman addressed the lack of significance of the basal energy expenditure drop in women, attributing it to the inclusion of data from just one study. “If data from that single study was removed the trend was also highly significant in females.”

"...The BMR plays a crucial role, accounting for around 60 to 75 percent of an individual’s total daily energy expenditure, particularly for those with sedentary jobs. This rate directly impacts the rate at which a person burns calories and ultimately influences whether a person maintains, gains, or loses weight. It is generally believed that the obesity epidemic has been primarily caused by decreased physical activity levels and increased food intake. However, the study revealed that physical activity levels have actually increased in both men and women, but the total energy expenditure has significantly decreased, alongside a corresponding decline in basal energy expenditure. One possible explanation is that increased physical activity during leisure time—such as jogging or swimming—is offsetting the progressive rise in sedentary behavior."
 
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CastorTroy

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Why there isn't that same obesity epidemic trend in Africa compared to most of so called "developed" countries?
 
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haidut

haidut

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Why there isn't that same obesity epidemic trend in Africa compared to most of so called "developed" countries?

It says right there in my post - 3rd world countries typically do not consume a lot of PUFA (as it is a product of mechanized agriculture), do not often use Western drugs, or have the same levels of persistent chronic stress. That is changing for some of those countries as they "modernize", and consequently their rates of "western" diseases and especially obesity/diabetes have skyrocketed. Look at obesity/diabetes rate changes in India and China over the last 50 years.
 

tankasnowgod

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Oh, and last but not least - what could be causing these declines in BMR? Well, chronic stress aside, that decline in BMR mirrors almost perfectly the curves of PUFA consumption rates in the general population. Namely, as the BMR curve has steadily declined over the last 100 years the PUFA consumption rate curve has steadily moved upwards over time. Unless this trend of ever-increasing PUFA consumption is interrupted, I don't see the decline of BMR flattening (let alone reversing) any time soon.
I don't know if you saw this video from Brad Marshall, but he apparently had a little exchange with the lead author of the study, John Speakman, on Twitter-


View: https://www.youtube.com/watch?v=nNNxE-K06KA


Brad's been doing some interesting research and personal experiments lately, and he has even featured some studies that suggest that MUFA might even be more fattening than PUFA. This would make pretty much all fat (except dairy, coconut, and cacao) problematic in any weight loss diet, as all other fat (even beef fat) is going to be mostly unsaturated (adding MUFA and PUFA together). Dairy fat (and cacao) is between 60-70% saturated, meaning you could probably get away with a little more, and Coconut Oil (or cream) might be beneficial to just add to the saturation, especially if you get hydrogenated. Otherwise, maybe opt for the leanest protein possible (chicken and turkey breast, tilapia, scallops, cod, gelatin powder), along with low fat milk and dairy (1% tastes light years better than skim, and it will be a mostly saturated fat). And for everything else, it's sugar ahoy!

Brad did also mention this study in one of his videos, where an ad libitum low-fat diet led to unexpected weight loss (and clinically significant weight loss) in many subjects. And they weren't trying to get the subjects to lose weight- One-year experience with a low-fat, low-cholesterol diet in patients with coronary heart disease

@haidut, might be a great time to do another podcast with Brad Marshall, if you can. He also did a day where he ate 800 grams of carbohydrate. He's been focusing on starch, as he thinks that fructose activate some of the desaturase enzymes, but I think the evidence he has pointed to in support of that is a bit weak. Like the Sterculia Oil study where they fed some of the experimental rats pure fructose in drinking water. Yes, the rats on the High Fructose diet did weigh more (though I think even the researchers said it wasn't statistically significant), but the high fructose rats were eating almost double the calories of the control rats, and getting more than 50% of total calories from pure fructose. Even then, those rats had low PUFA stores, but did have higher MUFA stores. Anyway, it'd be great to hear you two do another podcast about these topics (metabolic decline, NAD+/NADH, carbs in general, and fructose and sugar specifically).
 

burtlancast

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PUFAS are a factor in the obesity epidemic, but i believe the evidence for pesticides is overwhelming.

In the glyphosate study, the infinitesimal dose of 4 ng/kg/day was enough to multiply the blood triglyceride concentration in rats by a factor of 10 in 2 years.

Now let's think about that for a few seconds...
 

Ismail

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PUFAS are a factor in the obesity epidemic, but i believe the evidence for pesticides is overwhelming.

In the glyphosate study, the infinitesimal dose of 4 ng/kg/day was enough to multiply the blood triglyceride concentration in rats by a factor of 10 in 2 years.

Now let's think about that for a few seconds...
Wow!!! I did not know this! Thank you
 

burtlancast

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Wow!!! I did not know this! Thank you
triglycerides  +2016 study.png


 
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haidut

haidut

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PUFAS are a factor in the obesity epidemic, but i believe the evidence for pesticides is overwhelming.

In the glyphosate study, the infinitesimal dose of 4 ng/kg/day was enough to multiply the blood triglyceride concentration in rats by a factor of 10 in 2 years.

Now let's think about that for a few seconds...

Agreed. Well, at least glyphosate is now banned in the EU, isn't it? One less poison to worry about there. It is still used most everywhere else, AFAIK.
 
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haidut

haidut

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I don't know if you saw this video from Brad Marshall, but he apparently had a little exchange with the lead author of the study, John Speakman, on Twitter-


View: https://www.youtube.com/watch?v=nNNxE-K06KA


Brad's been doing some interesting research and personal experiments lately, and he has even featured some studies that suggest that MUFA might even be more fattening than PUFA. This would make pretty much all fat (except dairy, coconut, and cacao) problematic in any weight loss diet, as all other fat (even beef fat) is going to be mostly unsaturated (adding MUFA and PUFA together). Dairy fat (and cacao) is between 60-70% saturated, meaning you could probably get away with a little more, and Coconut Oil (or cream) might be beneficial to just add to the saturation, especially if you get hydrogenated. Otherwise, maybe opt for the leanest protein possible (chicken and turkey breast, tilapia, scallops, cod, gelatin powder), along with low fat milk and dairy (1% tastes light years better than skim, and it will be a mostly saturated fat). And for everything else, it's sugar ahoy!

Brad did also mention this study in one of his videos, where an ad libitum low-fat diet led to unexpected weight loss (and clinically significant weight loss) in many subjects. And they weren't trying to get the subjects to lose weight- One-year experience with a low-fat, low-cholesterol diet in patients with coronary heart disease

@haidut, might be a great time to do another podcast with Brad Marshall, if you can. He also did a day where he ate 800 grams of carbohydrate. He's been focusing on starch, as he thinks that fructose activate some of the desaturase enzymes, but I think the evidence he has pointed to in support of that is a bit weak. Like the Sterculia Oil study where they fed some of the experimental rats pure fructose in drinking water. Yes, the rats on the High Fructose diet did weigh more (though I think even the researchers said it wasn't statistically significant), but the high fructose rats were eating almost double the calories of the control rats, and getting more than 50% of total calories from pure fructose. Even then, those rats had low PUFA stores, but did have higher MUFA stores. Anyway, it'd be great to hear you two do another podcast about these topics (metabolic decline, NAD+/NADH, carbs in general, and fructose and sugar specifically).


Good point all around. I am pretty buys over the next 2-3 months, but may be able to do a podcast with him in late July or early August. Wondering if he managed to replicate the results of this study below with his 800g carb experiment.
 

aliml

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burtlancast

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Agreed. Well, at least glyphosate is now banned in the EU, isn't it? One less poison to worry about there. It is still used most everywhere else, AFAIK.
I'm afraid it's a partial ban only: the public can't buy it anymore, but agricultural professionals can still use it for the time being.

Not to mention the EU is importing tons of foods from all over the world from glyphosate countries, as long as the concentration limits are respected, which anyway are thousands times higher than 4 ng/kg/day.

This is why Europeans have found, according to who you believe, between 25% and 99% urine samples containing it.

And the UK will go the USA way and never ban it of course.
 
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lvysaur

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3rd world countries typically do not consume a lot of PUFA
They typically consume even more, the Western diet is one of the lowest PUFA diets in the modern world. (But even this is too high)
 

Jonk

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Maybe I'm reading into it too much but by just looking at how people in general walk it feels like we are much less capable as a species. It might be cultural to some extent. Not looking on a phone all the time, different shoes, more freedom to "be you" etc. But I wonder how much of it is just general degeneration of our physiology - low metablic rate, endotoxin etc. Even though it might not look like we're complete Quasimodos, looking closely at how people walk you see things like jerky hip swaying, assymetrical swaying of the arms, hunched forward, uneven shoulders etc. When looking at the 1930's people at first they all look like they have some sort of long lost cultural integrity, a base of confidence in their presence. Looking closer at how they actually move there is a lot more uniformity between persons; relaxed shoulders and less lateral sway of the hips.

New York 2021:

View: https://youtu.be/yhkbg8p2Gts?t=228


New York 1930's:

View: https://www.youtube.com/watch?v=ePH--widhXk
 

lilsticky

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i bet coconut cream and coffee is all you need. i would maintain a phobia of all other fat sources for a while. that means mufa sources too
 

chimdp

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While I agree that pufa, glyphosate, and other things are contributing factors. Is no one going to address the elephant in the room of EMF/artificial lights coupled with a substraction of sunlight from indoor living, sunglasses, and sunscreens? That would be way more foundational than the others. It started with electric power grid and lights in the 1890s, then the increase of Wireless communication.
 

CoconutEffect

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While I agree that pufa, glyphosate, and other things are contributing factors. Is no one going to address the elephant in the room of EMF/artificial lights coupled with a substraction of sunlight from indoor living, sunglasses, and sunscreens? That would be way more foundational than the others. It started with electric power grid and lights in the 1890s, then the increase of Wireless communication.
It has to be partially that too. Also what men 40 and under weren't at some point damaged by pornography and video game addiciton. Like 99%?
 
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haidut

haidut

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Also what men 40 and under weren't at some point damaged by pornography

According to the latest studies, women in that same age "consume" almost as much porn as males, even though a lot fewer of them are celibate. Not to mention the now completely normalized and ubiquitous possession/usage of female "sex toys" like vibrators, mechanical dild*s, and various other...tools. Most men would still be laughed out of the room if they mentioned in a social gathering they bought/have something like...a flesh-light. So, whatever is happening is affecting both sexes, just as obesity is.
 

chimdp

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It has to be partially that too. Also what men 40 and under weren't at some point damaged by pornography and video game addiciton. Like 99%?
I agree. This actually ties into the EMF thing since blue/artificial light is a form of EMF and one of the most damaging since its been around a long time and is so prevalent, but has gotten exponentially worse with tech devices plus LED/CFL/Fluorescent lighting not to mention you are usually consuming those on RF emitting devices. With porn and video games you are getting the dopamine depletion, damage to melanopsin and photoreceptors from the blue light, and all the psychiatric issues that go with them.
 

Nick

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EMF is probably the main thing. I am quite convinced by Arthur Firstenberg's argument identifying electrification and all forms of artificial EMF as the primary source of the metabolic damage that causes obesity, heart disease, cancer and diabetes by interfering with the movement of the electrons in the mitochondria.
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

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