CDP-Choline enhances cerebral glucose metabolism, increases cerebral blood flow rate & brain ATP, & decreases the accumulation of lactate in the brain

[RenaissanceMan]

I know Ray is against choline supplementation but many nootropics users have had positive experiences with it for improving motivation, memory, and overall cognition.

CDP-Choline breaks down into uridine which has many dopaminergic effects on the body as well. @Hans wrote an article on this.

Effects of various cerebral metabolic activators on glucose metabolism of brain - PubMed

The effects of various metabolic activators on the glucose metabolism of the perfused cat brain have been investigated. (1) When the perfusion is done with the blood containing cytidine monophosphate, the glucose metabolism of the brain is enhanced, as compared to the perfusion with the blood...

pubmed.ncbi.nlm.nih.gov

"Citicoline enhances the incorporation of blood glucose into the brain and its metabolism in the brain. It increases slightly the cerebral blood flow rate and decreases the accumulation of lactate in the brain."

Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke - PubMed

Ischemic stroke is one of the leading causes of long-lasting disability and death. Two main strategies have been proposed for the treatment of ischemic stroke: restoration of blood flow by thrombolysis or mechanical thrombus extraction during the first few hours of ischemic stroke, which is one...

pubmed.ncbi.nlm.nih.gov

"Citicoline exhibits neuroregenerative effects and activates neurogenesis, synaptogenesis, and angiogenesis and enhances neurotransmitter metabolism. Acute and long-term treatment with citicoline is safe and in most clinical studies is effective and improves functional outcome."

 

[Vinny]

I know Ray is against choline supplementation but many nootropics users have had positive experiences with it for improving motivation, memory, and overall cognition.

CDP-Choline breaks down into uridine which has many dopaminergic effects on the body as well. @Hans wrote an article on this.

Effects of various cerebral metabolic activators on glucose metabolism of brain - PubMed

The effects of various metabolic activators on the glucose metabolism of the perfused cat brain have been investigated. (1) When the perfusion is done with the blood containing cytidine monophosphate, the glucose metabolism of the brain is enhanced, as compared to the perfusion with the blood...

pubmed.ncbi.nlm.nih.gov

"Citicoline enhances the incorporation of blood glucose into the brain and its metabolism in the brain. It increases slightly the cerebral blood flow rate and decreases the accumulation of lactate in the brain."

Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke - PubMed

Ischemic stroke is one of the leading causes of long-lasting disability and death. Two main strategies have been proposed for the treatment of ischemic stroke: restoration of blood flow by thrombolysis or mechanical thrombus extraction during the first few hours of ischemic stroke, which is one...

pubmed.ncbi.nlm.nih.gov

"Citicoline exhibits neuroregenerative effects and activates neurogenesis, synaptogenesis, and angiogenesis and enhances neurotransmitter metabolism. Acute and long-term treatment with citicoline is safe and in most clinical studies is effective and improves functional outcome."

View attachment 27022

1. So, these are animal studies, correct?
2. Why this thread is labelled anti-peat?

 

[Wolf]

I think much of the problems surrounding choline is taking the crappy form or in the form of eggs.
Choline bitartrate gave me bad sides as did eggs sans ginger or other digestive enzymes.
Citicoline continues to impress.

 

[RenaissanceMan]

1. So, these are animal studies, correct?
2. Why this thread is labelled anti-peat?

Only the first one is an animal study. All of the studies cited in the diagram were done on humans.

 

[Vinny]

Only the first one is an animal study. All of the studies cited in the diagram were done on humans.

Thanks

 

[Dr. B]

I think much of the problems surrounding choline is taking the crappy form or in the form of eggs.
Choline bitartrate gave me bad sides as did eggs sans ginger or other digestive enzymes.
Citicoline continues to impress.

what side effects did you get from eggs and choline bitartrate?
i get similr effects from creatine and choline bitartrate.
some hair loss itchy scalp, oily skin, more energy
whys citicholine better and what effects do you get from it

 

[milkboi]

I really enjoy Alpha GPC as a nootropic

 

[Mauritio]

I really enjoy Alpha GPC as a nootropic

Can you compare it to choline bitartrate, eggs or any other choline source?

 

[milkboi]

Can you compare it to choline bitartrate, eggs or any other choline source?

The only thing that feels comparable in its effects is nicotine. Eggs unfortunately aren’t subjectively noticeably nootropic to me and neither was choline bitartrate

 

[Mauritio]

The only thing that feels comparable in its effects is nicotine. Eggs unfortunately aren’t subjectively noticeably nootropic to me and neither was choline bitartrate

Interesting I might give it a shot ! Did you try cdp choline ?

 

[korpesh]

I really enjoy Alpha GPC as a nootropic

I second that Alpha GPC seems to be a really good supp. Just feels like it makes my brain work better overall.

 

[Michael Mohn]

Why would Peat be against choline and recommend the most choline rich foods liver & eggs?

 

[Mauritio]

Why would Peat be against choline and recommend the most choline rich foods liver & eggs?

I dont think he's anti-choline per se, is he ? I rather think he's against excessive acetylcholine.

 

[Michael Mohn]

I dont think he's anti-choline per se, is he ? I rather think he's against excessive acetylcholine.

I suspect some people think being against high acetylcholine means being against dietary choline intake and Peat never was.

 

[milkboi]

Interesting I might give it a shot ! Did you try cdp choline ?

Nope, not yet but I think CDP choline is basically a combination of the effects of Alpha GPC and Uridine Monophosphate (CDP C partly converts to Uridine) and I also really like Uridine. In fact, that is one sup that also feels comparable to Alpha GPC, although it has more of a dopaminergic rush to it.

 

[Mauritio]

Nope, not yet but I think CDP choline is basically a combination of the effects of Alpha GPC and Uridine Monophosphate (CDP C partly converts to Uridine) and I also really like Uridine. In fact, that is one sup that also feels comparable to Alpha GPC, although it has more of a dopaminergic rush to it.

Thx mate , I ordered some alpha CDP . I need some additional choline for when I take piracetam

 

[Dave Clark]

Anybody use DMAE, and what is the consensus on that compound here on the forum?

 

[Dr. B]

Why would Peat be against choline and recommend the most choline rich foods liver & eggs?

I dont think he's anti-choline per se, is he ? I rather think he's against excessive acetylcholine.

he is against all forms of supplementation due to its pro methylation effects (maybe something else too). he recommends high choline foods just to meet the minimum requirements of like 500mg or 550mg a day

choline bitartrate causes acne, oily skin and hair, increase of anxiety, maybe bit more energy for me...

 

[Wolf]

what side effects did you get from eggs and choline bitartrate?
i get similr effects from creatine and choline bitartrate.
some hair loss itchy scalp, oily skin, more energy
whys citicholine better and what effects do you get from it

Same side effects. You can trace it to allergenic proteins in the case of eggs if you take it with enzymes or some ginger tea. Choline bitartrate gives a bunch of agitation type effects and secondary skin effects.
For me citicoline dramatically boosts my cognitive energy and lets me keep going long after my day is over. It doesn’t seem to be causing me any strange effects like adrafanil.

 

[Mauritio]

he is against all forms of supplementation due to its pro methylation effects (maybe something else too). he recommends high choline foods just to meet the minimum requirements of like 500mg or 550mg a day

choline bitartrate causes acne, oily skin and hair, increase of anxiety, maybe bit more energy for me...

I also feel very agitated/anxious from choline bitartrate. I think its powerfully lowering blood sugar . My muscles also looks fuller ,which indicates that it's doing something to the liver .
What is weird though that I dont get even the slightest of these effects from choline from eggs .
Maybe it can't be absorbed that well.
There's a study suggesting that.

"The investigators have also recently shown a 10-fold increase in plasma TMAO levels following supplementation with choline bitartrate supplements [to amount 450mg of sucholine a day (original post above)]. However, another pilot study by a collaborator (unpublished) did not show the same increase in plasma TMAO levels following the ingestion of whole eggs, a major dietary source of choline. Therefore, with this study the investigators wish to examine the differences, if any, between the ingestion of an equivalent mass of total choline in the free form (as bitartrate salt) as a supplement vs. within whole eggs."
(Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans - Full Text View - ClinicalTrials.gov)