David PS
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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Highlights•CD38 levels increase in tissues with age and correlate with NAD decline
•NAD and mitochondrial function are preserved in old CD38 knockout mice
•CD38 metabolizes NMN in vivo and modulates the response to NAD-replacement therapy
NAD has a number of potential positive effects in the body.
from Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Supplement manufacturers have focused on marketing NAD precursors rather than CD38 inhibitors. The NAD precursors are molecules that can be used by cells and tissues to make NAD. They include nicotinamide and vitamin B3 and very expensive alternatives such as nicotinamide riboside (NR) and nicotinamide mono nucleotide (NMN).
CD38 Inhibitors
See the Table at page 26 of this reference.
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Quercetin is shown to be a CD38 inhibitor.
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the m
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