I disagree. What article are you citing in regards to schizophrenics having very high dopamine? I've only come across the opposite, in fact.
I fully expect that methheads would have low dopamine as well, from consistent abuse to the endogenous dopamergenic system.
Dude, I’m not citing “an” article. The role of dopamine in schizophrenia has been studied since the sixties. There is a comprehensive discussion in this article: The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue
Methamphetamine increases dopamine release and inhibits its reuptake. I refuse to even take the time to cite a source. You can find this information easily. Anybody on meth currently is walking around with insanely spiked dopamine. Like you could never even dream of. But don’t try it at home.
My post was a little bit tongue-in-cheek. If you knew me personally, you would understand that much of what I say is half-serious and half-joking in order to provoke thought.
I think schizophrenia has to do with too much estrogen. Your dopamine can get really high without problems if you have enough thyroid/progesterone/CO2 at the same time. But if you have too much estrogen/toxic metal buildup stimulating glutamate, even a mild dopamine increase will cause psychotic symptoms.
Meth abuse is a very "estrogenic" kind of dopamine because it doesn't support the CNS stimulation with enough CO2.