Cascara Sagrada Causing Constipation

ddjd

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I've never had a problem with constipation so never bothered with cascara Sagrada. But I read something from @haidut recently about it being a 5ht2a antagonist, so gave it a go and I'm completely constipated. But it's meant to be a laxative so surely would have the opposite effect???

Anyone else had constipation from it?
 

DaveFoster

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It's better to use it regularly, as it can lower gut inflammation and interrupt serotonin release from platelets, which minimizes peristalsis in the next series of bowel movements.
 
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ddjd

ddjd

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It's better to use it regularly, as it can lower gut inflammation and interrupt serotonin release from platelets, which minimizes peristalsis in the next series of bowel movements.
Is it best to take before bed?
 

DaveFoster

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Is it best to take before bed?
It can help you sleep, and many report benefits from having a bowel movement earlier in the day (as in the following morning).
 

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