Cardiolipin and linoleic acid

hclh

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Jun 3, 2016
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Cardiolipin is a fundamental lipid in the inner mitochondrial membrane. Defects in that membrane can lead to lack of ATP building capacity and in the end, to the mitochondria destruction.
One could then think that the building blocks of cardiolipin should be as strong as posible.
But in real life it seems it is not the case.
Cardiolipin is made of fatty acids and it seems, acording the literature, that the mainly chosen fatty acid is linoleic acid over another fatty acids.
Why?
Everybody here knows that PUFA and linoleic acid are much easier to form oxides and become damaged and despite that, the body normaly uses it for making cardiolipin.
Why? Any idea?
 
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