Can someone explain the difference between hormone antagonism and lowering plasma level?

Stella123

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"However, receptor antagonists (e.g. cyproheptadine) typically do not decrease plasma levels of the hormone/substance they are antagonizing."- Georgi

I get it in the sense the effects of hormones can be diminished by an atagonist. And some substances can actually lower the hormones.

But how is this distinguished? Which avenue is better?

Just looking for some more info on what this means?

For example, does progesterone antagonize estrogen or lower it?

It sounds like vitamin E does both. Is there a list of substances that do both or have just one action?
 
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