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Calcirol - Liquid Vitamin D3

Discussion in 'IdeaLabs' started by haidut, Dec 10, 2017.

  1. raypeatclips

    raypeatclips Member

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    Okay, thanks for the info. Any other absorption enhancers in the works?
     
  2. OP
    haidut

    haidut Member

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    Possibly, but nothing confirmed yet.
     
  3. Amazoniac

    Amazoniac Member

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  4. OP
    haidut

    haidut Member

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    The point about infections causing low 25-OH-D and high 1,25-OH-D is probably accurate. As I mentioned many times before, testing 25-OH is probably inadequate to draw conclusions about vitamin D status. It should always be tested with 1,25-OH, PTH, calcium, phosphorus and maybe even WBC, CRP, and ESR.
     
  5. Amazoniac

    Amazoniac Member

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    :handpointup:
    "Rickets is often cited as proof of the need for vitamin D supplementation. However, a review of the metabolic processes involved provides some prospective. Adequate vitamin D is essential to prevent rickets, but adequate calcium is equally important; if either calcium or vitamin D is deficient, bone health suffers. Hypophosphatemia is the common denominator of all rickets; low calcium intake leads to hyperparathyroidism, which leads to high phosphorus excretion and, thus, phosphorus deficiency [44]."

    The person might feel a relief from increase in phosphate and decrease in calcium at first, but what's needed is the opposite and working the way up with the slowlies.
     
  6. Amazoniac

    Amazoniac Member

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  7. Wagner83

    Wagner83 Member

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    You're one of the very few people I've seen who learns so much from himself.
     
  8. raypeatclips

    raypeatclips Member

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    I was wondering where you got the 30% topical absorption rate from? I didn't see the studies in the first page of the post? With calcirol released for nearly 6 months now, do you have any theories on what % absorption rate calcirol could be?
     
  9. OP
    haidut

    haidut Member

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    Lol, me or Amazoniac?
     
  10. OP
    haidut

    haidut Member

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    I meant what Peat said when asked about topical absorption of fat-soluble vitamins dissolved in oil. He said he does not know exactly but thinks 25%-30% is about right. The studies with steroids and the SFA ester we use show up to 90% absorption of some steroids and since vitamin D is also a steroid (secosteroid) I was guessing it would have similar absorption profile or at the very least higher than 30%.
    Don't have many lab reports from people but the few that I did get showed vitamin D3 jumping from the low 20s to mid 40s from 5-6 drops daily for a few weeks.
     
  11. Wagner83

    Wagner83 Member

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    I was joking with the fact that He quotes himself a lot.
     
  12. Amazoniac

    Amazoniac Member

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    https://www.westonaprice.org/health-topics/abcs-of-nutrition/update-on-vitamins-a-and-d/

    "Are some people pushing their vitamin D levels too high? Has science proven that the minimal acceptable blood level of vitamin D, in the form of 25(OH)D, is above 50 ng/mL (125 nmol/L)?

    The answer is “No.” If you’ve been trying to maintain your levels this high because you thought this was the case, I’m sorry to break the news. There is, on the contrary, good evidence that 25(OH)D levels should be at least 30-35 ng/ mL (75-88 nmol/L). Much higher levels may be better, or they could start causing harm, especially in the absence of adequate vitamins A and K2. Once we leave the land of 30-35 ng/mL, however, we enter the land of speculation."

    "the point at which the vitamin D enzymes are saturated and vitamin D “accumulates within the body, both in serum and probably in body fat” is not 40 or 50 ng/mL (100 or 125 nmol/L) but rather 35 ng/mL (88 nmol/L)."

    "We [] have some strong support for raising 25(OH)D levels to at least 35 ng/mL (88 nmol/L)."

    "What about higher levels? The evidence is conflicting, and some of it indicates possible harm. For example, a study in the American Journal of Medicine published in 2004 found that in Americans aged over fifty, the maximal bone mineral density (BMD) occurs around 32-40 ng/mL (80- 100 nmol/L). Among Mexican Americans, BMD continues to rise a little after this point, but for whites it plateaus and begins dropping off around 45 ng/mL (110 nmol/L) and for blacks it begins dropping off even before 40 ng/mL (100 nmol/L).

    If 50 ng/mL (125 nmol/L) is our minimal acceptable level, this study would seem to suggest that those of us who have “acceptable” levels of 25(OH)D would have lower bone mineral density than those of us who are moderately deficient. And that premise just doesn’t make sense."

    "Lifeguards in the tropics can reach blood levels in the 50s and 60s naturally from sun exposure, suggesting these levels are “natural,” although lifeguards in Israel have twenty times the rate of kidney stones as the general population."

    "Kidney stones may be the most sensitive indicator of vitamin D toxicity and are a symptom of vitamin A and K2 deficiency. Thus, I suspect these levels are healthful in the context of a diet rich in vitamins A and K2, and if my levels were to reach this high in the summer sun while I was eating such a diet, I certainly would not worry.

    But if you are trying desperately to maintain year-round 25(OH)D status between 50-80 ng/ mL using vitamin D supplements, you have entered the land of speculation. Enter at your own risk."
     
  13. bzmazu

    bzmazu Member

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    Great info for those with access to labs...or with the money to pay for labs...what about the millions w no testing?...I know I'll get the pertinent info now?...
     
  14. Amazoniac

    Amazoniac Member

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  15. Lejeboca

    Lejeboca Member

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    Just wanted to add my 2 cents worth of experience. I am using it on temples 1-2 drops per temple and I've felt an amazing affect: Absence of jet-lag traveling either direction (east/west) from the US; this is in addition to feeling more energy generally, as reported by other users.
     
  16. OP
    haidut

    haidut Member

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    Excellent, thanks for the feedback! Does it help with allergies? A few people said putting it on their temples stopped their seasonal allergies and sneezing.
     
  17. Lejeboca

    Lejeboca Member

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    I don't have seasonal allergies but I do get some mucus and sneezing reactions when handling ivy or rag-weed too much in the yard. I must admit that I felt much less of those this year with calcirol 'on' than last year without (and with no other changes).
     
  18. OP
    haidut

    haidut Member

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    Nice, thanks for sharing!
     
  19. jaakkima

    jaakkima Member

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    What results would indicate good Vitamin D status then? As I posted in a previous thread, I suspect I have some stubborn infection(s). I'd been using 10k Calcirol for a few months topically but my 25, hydroxyvitamin D lab actually dropped from 31 to 21 in that time, despite sun and supplementing. I just switched to try orally instead. It makes me feel better using it but maybe I should get more tests. Don't want to do harm, especially given I'm still on a Vitamin K Antagonist.
     
  20. managing

    managing Member

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    just used this (one drop, forearm) for the first time this afternoon. Knocked me out for two hours. Woke up with mild left hemisphere headache.

    ?????????
     
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