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Calcirol - Liquid Supplement With Vitamin D3

Discussion in 'IdeaLabs' started by haidut, Dec 10, 2017.

  1. OP
    haidut

    haidut Member

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    Not bad, if it does not irritate the stomach as malate salts tend to do.
     
  2. OP
    haidut

    haidut Member

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    So, what does that mean? Useless without vitamin D or useless below the doses of vitamin D used.
     
  3. OP
    haidut

    haidut Member

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    Excellent, thanks for the feedback!
     
  4. Amazoniac

    Amazoniac Member

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    Useless within the range that they employ. I suspect that only mk-7 was used (not sure!), and perhaps it would change the whole story if mk-4 was used instead. It's up to the patient to use it or not.
    He says that high doses of vit D have a marked action on calcium deposition but also removal from bones to the point of risking net loss. In practice he found that there are two ways to counteract the loss: brief (30 min) daily exercise, according to him, calcitonin is involved; or the classic bisphosphonates.

    Regarding calcium restriction, he comments that it can vary. Some people have to adhere when doses are lower than 10000IU whereas some can handle doses up to 20000IU without needing to restrict. I believe everyone above 20000IU is advised to avoid calcium-rich foods. He claims that doses of at least 7000IU are needed to replete deficiencies in his experience.
     
  5. OP
    haidut

    haidut Member

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    What is the proposed mechanism for vitamin D removing calcium from bones?? AFAIK, vitamin D is one of the few agents known to increase osteocalcin synthesis, which lowers bone resoprtion/turnover and increases osteoblast formation. So, it should have bone building effects regardless of the dose, especially when combined with vitamin K (which also raises osteocalcin).
     
  6. Amazoniac

    Amazoniac Member

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    Zeus, I'm not sure if he ever explained in detail why exactly, if I come across I'll let you know. But from his brief mentions, I think it's because the vit D resistance that some people experience is not generalized, the doses needed in enough amounts for a therapeutic effect can surpass those that are related to calcium regulation, so the effect on calcium deposition from those doses is so strong that the person is at risk of constantly responding to the lowered calcium with its removal from bones.
     
  7. OP
    haidut

    haidut Member

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    Thanks, if you do find his explanation please send. I don't know of a mechanism by which vitamin D will increase calcium deposition so much that it would lead to leeching from the bones to deposit...again in the bones.
     
  8. Amazoniac

    Amazoniac Member

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    No, I mean, if anything, to keep blood levels in range and stable.
    As a related example, he often mentions the risk of excessive PTH suppression to undetectable levels followed by hypercalcemia and kidney damage.
     
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