Caffeine sensitisation

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Hello, dear peats, I found this study(Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release - PubMed, Subchronic caffeine administration sensitizes rats to the motor-activating effects of dopamine D(1) and D(2) receptor agonists - PubMed) on dopamine sensitization through subchronic caffeine administration. I wanted to ask how would you extrapolate the data from the study, in the sense of what frequency of caffeine intake would be relevant for a person to achieve caffeine sensitization, according to my logic, this is once every ~ 72 hours (I multiplied the longest half-life of caffeine in humans by 10)
@haidut
 
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