Sativa
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- Joined
- May 17, 2018
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- 400
Here's a great insight on succinic acid promoting steroidogenesis! (aka pregnenolone, DHEA...)
"Succinic acid has a myriad of health effects...its main metabolic effect is the stimulation of the Krebs cycle activity...increasing ATP synthesis."
And a new one - fumaric acid! (forming fumarate salts)
- Fumarate is an intermediate in the Krebs cycle -
Haidut explains:Szent-Gyorgyi found that succinic acid stimulates respiration, which might
explain why it promotes synthesis of pregnenolone and related steroids.
Ray Peat - The Generality of Adaptogens
"Succinic acid has a myriad of health effects...its main metabolic effect is the stimulation of the Krebs cycle activity...increasing ATP synthesis."
Re GABA –Succinic acid increases steroidogenesis in the adrenals, and possibly in the gonads as well. So, it likely raised pregnenolone/DHEA levels and possibly T. Also, given that it raises ATP synthesis rather well, and ATP is a cofactor for StAR and steroid synthesis, that contributes to better steroidogenesis too. Finally, succinic acid is both a precursor and metabolite of GABA and raising GABA sometimes has pro-dopamine and anti-serotonin effects
Additionally –GABA has a wide range of stress-blocking actions, including neural inhibition, progesterone promotion, and blood sugar regulation.
Since succinic acid safely chelates toxic heavy metals out of mitochondria, it might also safely carry copper into the mitochondria.
Succinic acid works even better when combined with methylene blue (MB) as the combination can bypass any mitochondrial damage and produce ATP/CO2 even in very sick people.
i have had a great response to BioCare's Mag succinate/Cal succinate (2:1). Nothing at all like straight succinic acid.
And a new one - fumaric acid! (forming fumarate salts)
- Fumarate is an intermediate in the Krebs cycle -
It [succinic acid] and fumaric acid are now considered to be adaptogens./QUOTE]
Cue Sodium/Calcium/Magnesium/Caffeine fumarate...
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