Caffeine Lowers Parathyroid Hormone (PTH)

haidut

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The study tested both calcium and caffeine. Caffeine had a significant effect at a dose of about 300mg for a human. Calcium had a biphasic effect - lower dose of calcium increased PTH, while a higher dose lowered it. The high dose calcium was equivalent to a human dose of about 1,500mg - 2,000mg calcium, which is within the ranges Peat recommends.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207951/

"...Possible effects of caffeine on PTH secretion were determined by batch incubation studies of human parathyroid adenoma cells. Three physiologically relevant concentrations of caffeine were evaluated: 1, 10, and 50 μm. Caffeine treatment was applied for periods of 30 minutes in each plate. The results are summarized in Figure 1. Treatment with 50 μm caffeine led to a significant inhibition by 10.4% (25th, 75th percentiles: 7.6, 21) of PTH secretion compared with control (P < .05). For comparison, 0.5 mm Ca2+ caused a 12.4% (0.2, 47.8) increase, whereas 1.8 mm Ca2+ led to a 30.5% (9.8, 41.5) decrease of PTH secretion."

Finally, since caffeine is an often used supplement in Peat-world, and many studies on it are in vitro, here is a human study showing that 250mg caffeien achieved 40micoMol concentration in adult humans. This means that to get an identical effect of caffeine as the uncoupler DNP, a person would need about 6 * 250mg caffeine.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372487/
"...For instance, a mean blood caffeine concentration of ∼ 22 µM was reported in pregnant women at 36 weeks of gestation [44], while a plasma concentration of 40 µM caffeine and 20 µM paraxanthine was observed in humans after ingestion of 250 mg of caffeine [45]. Recently, one study showed that plasma levels of caffeine were between 1–50 µM in umbilical cords of preterm newborns [46]."
 
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Perhaps that is why a glass a day increases fractures in post-menopausal women.
 
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haidut

haidut

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Such_Saturation said:
https://raypeatforum.com/forums/posts/98045/ Perhaps that is why a glass a day increases fractures in post-menopausal women.

That's what I thought, especially considering the other studies showing increased prolactin from 500mg per day but lower prolactin from 1,000mg+ per day.
 
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The hard part is getting a post-menopausal person to drink anything more than one glass :ss
 

yourke

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The study tested both calcium and caffeine. Caffeine had a significant effect at a dose of about 300mg for a human. Calcium had a biphasic effect - lower dose of calcium increased PTH, while a higher dose lowered it. The high dose calcium was equivalent to a human dose of about 1,500mg - 2,000mg calcium, which is within the ranges Peat recommends.

Inhibition of Parathyroid Hormone Secretion by Caffeine in Human Parathyroid Cells

"...Possible effects of caffeine on PTH secretion were determined by batch incubation studies of human parathyroid adenoma cells. Three physiologically relevant concentrations of caffeine were evaluated: 1, 10, and 50 μm. Caffeine treatment was applied for periods of 30 minutes in each plate. The results are summarized in Figure 1. Treatment with 50 μm caffeine led to a significant inhibition by 10.4% (25th, 75th percentiles: 7.6, 21) of PTH secretion compared with control (P < .05). For comparison, 0.5 mm Ca2+ caused a 12.4% (0.2, 47.8) increase, whereas 1.8 mm Ca2+ led to a 30.5% (9.8, 41.5) decrease of PTH secretion."

Finally, since caffeine is an often used supplement in Peat-world, and many studies on it are in vitro, here is a human study showing that 250mg caffeien achieved 40micoMol concentration in adult humans. This means that to get an identical effect of caffeine as the uncoupler DNP, a person would need about 6 * 250mg caffeine.
Caffeine Reduces 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in Human Trophoblast Cells through the Adenosine A2B Receptor
"...For instance, a mean blood caffeine concentration of ∼ 22 µM was reported in pregnant women at 36 weeks of gestation [44], while a plasma concentration of 40 µM caffeine and 20 µM paraxanthine was observed in humans after ingestion of 250 mg of caffeine [45]. Recently, one study showed that plasma levels of caffeine were between 1–50 µM in umbilical cords of preterm newborns [46]."


parathyroid hormone is now given as bone building medicine, any thoughts?

In addition to treating osteoporosis, PTHs may be used to promote fracture healing, to restore bone loss in immobilized patients, or following excessive glucocorticoid or prolonged spaceflight, and to treat psoriasis.
Parathyroid hormone: an anabolic treatment for osteoporosis.
Morley P1, Whitfield JF, Willick GE.

In all studies reported to date, PTH appears to be well tolerated. The era of anabolic therapy for osteoporosis is at hand, with PTH being the first to be tested with sufficient rigor to demonstrate its efficacy.
The potential of parathyroid hormone as a therapy for osteoporosis.
Rubin MR1, Bilezikian JP.


Markers of bone formation and resorption increased in the PTH arm reaching a peak between 9 and 12 months of therapy and declining thereafter. Parathyroid hormone was well tolerated. These results suggest that low-dose intermittent PTH may be an efficacious therapy for men with idiopathic osteoporosis.
Therapy of male osteoporosis with parathyroid hormone.
Bilezikian JP1, Kurland ES.
 
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haidut

haidut

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parathyroid hormone is now given as bone building medicine, any thoughts?

In addition to treating osteoporosis, PTHs may be used to promote fracture healing, to restore bone loss in immobilized patients, or following excessive glucocorticoid or prolonged spaceflight, and to treat psoriasis.
Parathyroid hormone: an anabolic treatment for osteoporosis.
Morley P1, Whitfield JF, Willick GE.

In all studies reported to date, PTH appears to be well tolerated. The era of anabolic therapy for osteoporosis is at hand, with PTH being the first to be tested with sufficient rigor to demonstrate its efficacy.
The potential of parathyroid hormone as a therapy for osteoporosis.
Rubin MR1, Bilezikian JP.


Markers of bone formation and resorption increased in the PTH arm reaching a peak between 9 and 12 months of therapy and declining thereafter. Parathyroid hormone was well tolerated. These results suggest that low-dose intermittent PTH may be an efficacious therapy for men with idiopathic osteoporosis.
Therapy of male osteoporosis with parathyroid hormone.
Bilezikian JP1, Kurland ES.

This is quite misguided and dangerous. PTH increases when calcium intake and blood levels fall. It's role it to get more calcium in the blood. PTH does this by increasing calcium absorption from the intestine by increasing conversion of vitamin D3 into the "active" vitamin D called calcitriol. However, PTH also increases prolactin so the net effect can be quite detrimental to the bone. If a person gets PTH as a drug and does not also increase calcium intake then it will shed their bones by elevating prolactin. Type "PTH prolactin" in Google.
 

yourke

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This is quite misguided and dangerous. PTH increases when calcium intake and blood levels fall. It's role it to get more calcium in the blood. PTH does this by increasing calcium absorption from the intestine by increasing conversion of vitamin D3 into the "active" vitamin D called calcitriol. However, PTH also increases prolactin so the net effect can be quite detrimental to the bone. If a person gets PTH as a drug and does not also increase calcium intake then it will shed their bones by elevating prolactin. Type "PTH prolactin" in Google.

Thanks, yes, Dr. is trying to prescribe it to my father-inlaw (together with vit.D3 and calcium).
I told him not to take it as PTH increase serotonin and histamine
(Induction of mast cell secretion by parathormone.
Tsakalos ND, Theoharides TC, Kops SK, Askenase PW.)

But who can argue against a Dr.
 

SolidSteele

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Thanks, yes, Dr. is trying to prescribe it to my father-inlaw (together with vit.D3 and calcium).
I told him not to take it as PTH increase serotonin and histamine
(Induction of mast cell secretion by parathormone.
Tsakalos ND, Theoharides TC, Kops SK, Askenase PW.)

But who can argue against a Dr.

They prescribed PTH and Vitamin D. That seems very counter-intuitive considering the standard Vitamin D test is based on levels measured against the suppression of PTH.
 

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