jandrade1997
Member
- Joined
- Nov 7, 2013
- Messages
- 61
I'm trying to understand the Peatish position on this. I know Peat is a huge fan of GABA, for instance:
"The similarity between the structures and actions of glycine and GABA suggest that their “receptors” are similar, if not identical. For years, it has been known that progesterone and pregnenolone act on the GABA receptor, to reinforce the protective, inhibitory effects of GABA. Estrogen has the opposite effect, inhibiting GABA's action. Since GABA opposes estrogen and inhibits the growth of breast cancer, it wouldn't be surprising if glycine, alanine, etc., did the same."
But I've read some literature that pretty uniformly suggests that caffeine inhibits GABA release.
http://www.ncbi.nlm.nih.gov/m/pubmed/14664509/
http://www.ncbi.nlm.nih.gov/m/pubmed/2835648/
So, GABA seems to be extremely important, arguably the principle governor of protective inhibition (a role for which glycine seems to serve as an analogue and partial replacement). So how significant is caffeine's pretty potent inhibition of GABA? I would argue quite significant but many people on this forum know more than I. Ray Peat seems to suggest that protective inhibition is one of the primary ways to regenerate tissue is some of his newsletters. As such, should we be concerned about caffeine's inhibition of protective inhibition?
"The similarity between the structures and actions of glycine and GABA suggest that their “receptors” are similar, if not identical. For years, it has been known that progesterone and pregnenolone act on the GABA receptor, to reinforce the protective, inhibitory effects of GABA. Estrogen has the opposite effect, inhibiting GABA's action. Since GABA opposes estrogen and inhibits the growth of breast cancer, it wouldn't be surprising if glycine, alanine, etc., did the same."
But I've read some literature that pretty uniformly suggests that caffeine inhibits GABA release.
http://www.ncbi.nlm.nih.gov/m/pubmed/14664509/
http://www.ncbi.nlm.nih.gov/m/pubmed/2835648/
So, GABA seems to be extremely important, arguably the principle governor of protective inhibition (a role for which glycine seems to serve as an analogue and partial replacement). So how significant is caffeine's pretty potent inhibition of GABA? I would argue quite significant but many people on this forum know more than I. Ray Peat seems to suggest that protective inhibition is one of the primary ways to regenerate tissue is some of his newsletters. As such, should we be concerned about caffeine's inhibition of protective inhibition?