Dan W
Member
- Joined
- Jan 22, 2013
- Messages
- 1,528
I finally managed to post a study before Haidut's high-powered laser-guided tracking system could beat me to it.
Caffeine Restores Insulin Sensitivity and Glucose tolerance in High-sucrose Diet Rats: Effects on Adipose Tissue
The concentrations necessary might not be as high as they sound initially. This discussion on SuppVersity suggests ~16 mg/kg in humans after accounting for Wistar rats and their lack of drinkin' much.
Caffeine Restores Insulin Sensitivity and Glucose tolerance in High-sucrose Diet Rats: Effects on Adipose Tissue
Chronic caffeine administration improved whole-body glucose homeostasis and insulin signaling pathways in adipose tissue in [high sucrose] animals in a concentration dependent manner.
We also concluded that chronic caffeine administration avoids visceral and total fat accumulation in a concentration dependent manner in [high sucrose] animals, without altering animal’s body weight. Although caffeine did not directly affect [insulin receptor] expression in the adipose tissue, it stimulates the insulin signaling cascade. Therefore, we can suggest that this may be one of the mechanisms for caffeine-induced improvement of insulin sensitivity in [high sucrose] rats.
The concentrations necessary might not be as high as they sound initially. This discussion on SuppVersity suggests ~16 mg/kg in humans after accounting for Wistar rats and their lack of drinkin' much.