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Caffeine extends lifespan in animal model by 52%

Discussion in 'Scientific Studies' started by haidut, Jul 26, 2013.

  1. haidut

    haidut Member

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    Several other drugs achieved similar effects, but caffeine did best in extending both average and maximal lifespan. I have not seen any other naturally found compound come even close to extending life by so much. The human dosage equivalent according to the researchers is 100mg-200mg every 4h, so this would be 600mg-1200mg per day. Here are some studies:

    FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity
    Caffeine extends yeast lifespan by targeting TORC1. - PubMed - NCBI

    Keep in mind this was pure caffeine study, not coffee or any other drink containing caffeine. So, in theory caffeine pills should be the way to go for replication, but I am sure coffee won't hurt either given its other good compounds.
     
  2. chris

    chris Member

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    Thanks for posting this! I am tempted to buy some caffeine usp as well as aspirin usp powder, wonder if it would work out cheaper than using an OTC aspirin+caffeine combo.
     
  3. Dan Wich

    Dan Wich Member

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    I'm thinking about this too, given 11 cents a gram for caffeine and 2 cents a gram for aspirin (assuming you are a horse). Wish we could find some pure aspirin intended for human consumption...
     
  4. chris

    chris Member

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    There is no problem with that aspirin is there? Other than the labelling of "horse" putting some people off.
     
  5. 4peatssake

    4peatssake Member

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    I think this may be the only side effect. ;)

    [​IMG]
     
  6. juanitacarlos

    juanitacarlos Member

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  7. Vinero

    Vinero Member

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    This is amazing! 52 % lifespan extension from caffeine alone!
    So if I were to live 60 years of age it would mean I would live to 90 if I took large doses of caffeine every day?
    Here another study showing the awesome effects of caffeine on hormones progesterone and pregenelone:
    http://www.ncbi.nlm.nih.gov/pubmed/10837842
    Would there be a difference between pure powedered caffeine and coffee?
     
  8. kiran

    kiran Member

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    Life extension is usually way less dramatic in higher organisms. This is not at all to put down caffeine.
     
  9. Philomath

    Philomath Member

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    This would make sense as Ray Peat said caffeine is similar in action to T3.
     
  10. Jenn

    Jenn Member

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    Just remember the caffeine still needs to be accompanied by fuel/nutrition for the liver....so why not eat it with food, as in coffee?
     
  11. j.

    j. Guest

    Because after consuming as much coffee and chocolate as I can, and 2 liters of coca cola, I still want more caffeine.
     
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