Caffeine Decreases Nitric Oxide (NO) , Cox-2 Inhibitor

[sladerunner69]

Yes, but they're guilty of systematic dogma; they're tests are presumably accurate for things like heavy metals.

I suppose that the pharmaceutical grade distinction is really only useful for heavy metal toxicity anyways

 

[richofden]

Didn't see this posted and is a fairly new study. Also, does anyone any ideas how this relates to endotoxin? I am quite new at looking at studies.

Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. - PubMed - NCBI

" Caffeine decreased the LPS-induced inflammatory mediator, nitric oxide (NO). Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells."

il-12 BIOLOGICAL FUNCTIONS: NK cell and T lymphocyte stimulation.USES: Regulation of cell-mediated immune response. Complementary treatment of allergy.• allergy• food intolerance• complementary cancer therapy• recurrent night-time cough• nasal congestion and nasal itching• paroxysmal sneezing• watery eyes due to allergy• skin swelling and skin inflammation. So if caffeine reduces expression of this cytokine, that can´t be good?