Brunner Syndrome

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Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene.

Brunner syndrome is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and norepinephrine (noradrenaline). In both mice and humans, a mutation was located on the eighth exon of the MAO-A gene, which created a dysfunctional MAO-A gene. The regular function of MAO-A, breaking down monoamines, is disrupted, and monoamines build up within the brain. Mice that lacked a functional MAO-A gene displayed higher levels of aggression, in comparison to mice with a functional MAO-A gene

Characteristic biochemical abnormalities included high serum serotonin .

Symptomatic individuals have particularly high serotonin levels, and treatment with a serotonin reuptake inhibitor and dietary modification resulted in reversal of biochemical abnormalities, reduction of 'serotonergic' symptoms and behavioural improvement.

Any thoughts on this?
 
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Gonna try something called Peganum harmala

''. A study published in the 2009 issue of Food and Chemical Toxicology found that harmaline and harmine in the seed extracts of Peganum harmala were potent MAO-A inhibitors; and harmine in the root extract was an active MAO-A inhibitor.''

(EDIT) hm nevermind I think i got it wrong. the more MAO activity you have the less neurotransmitters you end up with I thought it was the other way around if you slowed down MAO activity you would have less serotonin etc.. can someone help me understand?

Common Herbs With MAO Inhibitor Activity
 
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OP
M

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What is something that increases MAO-A activity?

(EDIT) Might try something like Apigenin , Luteolin or Valproic Acid
 
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