Brain Issues And Loss In Ability To Utilize Sugar

yoshiesque

Member
Joined
Mar 9, 2014
Messages
365
I know that one of the big issues with brain disorders can be the fact that the brain just cant use sugars/glucose anymore as fuel. so when they switch to fat only diets their brain seems to thrive. now i know such a diet is not good in the long run, but what would one do to restore the utilization of sugar as energy in the brain? I know that Ray Peat talked about potato juice being beneficial here, BUT that kinda makes me feel like once the brain has lost its ability (whether partial or complete) to use sugar/glucose as fuel, thats it, it cant be reversed?
 
Joined
Nov 11, 2014
Messages
584
yoshiesque said:
...BUT that kinda makes me feel like once the brain has lost its ability (whether partial or complete) to use sugar/glucose as fuel, thats it, it cant be reversed?

This is largely what Alzheimer's researchers are beginning to look into now that they're seeing it's a problem of glucose oxidation.

The brain is another organ, like our kidneys and liver, so improving the body's ability to handle sugar will also improve the brain's ability to handle sugar.
 

jimmyquick

Member
Joined
Dec 8, 2014
Messages
46
cantstoppeating said:
yoshiesque said:
...BUT that kinda makes me feel like once the brain has lost its ability (whether partial or complete) to use sugar/glucose as fuel, thats it, it cant be reversed?

This is largely what Alzheimer's researchers are beginning to look into now that they're seeing it's a problem of glucose oxidation.

The brain is another organ, like our kidneys and liver, so improving the body's ability to handle sugar will also improve the brain's ability to handle sugar.


Remember the story of the women who fed her husband coconut oil because he had Alzheimer's who then drastically improved? I think I remember listing to a podcast with the women being interviewed on Dave Asprey's podcast and him telling her it was helping her husband only because the brain actually favors those type of saturated and MCT fats over glucose.

However, I believe there was another podcast with Ray explaining that he was improving because the coconut fats were actually displacing the PUFA in the brain, thus allowing it to better utilize the glucose and improve (please someone correct me if Im wrong or post the podcast link, I cant remember them all!) but I think I am remembering this right. If this is the case, then the brain never loses it's ability. The fat is clearing out the PUFA which allows them to thrive.

I would love to know what the gentleman's (patient) diet was like before he started developing brain issues. I wouldn't be surpriesed if he was ingesting a good amount of questionable oils. If he was always eating healthy from the get go then perhaps that would favor the more "brain losses its ability" theory. I think the women who was doing this actually has a website and is quite active online about it.
 

haidut

Member
Joined
Mar 18, 2013
Messages
17,433
Location
USA / Europe
yoshiesque said:
I know that one of the big issues with brain disorders can be the fact that the brain just cant use sugars/glucose anymore as fuel. so when they switch to fat only diets their brain seems to thrive. now i know such a diet is not good in the long run, but what would one do to restore the utilization of sugar as energy in the brain? I know that Ray Peat talked about potato juice being beneficial here, BUT that kinda makes me feel like once the brain has lost its ability (whether partial or complete) to use sugar/glucose as fuel, thats it, it cant be reversed?

You can use substances that increase the oxidation of sugar. Some of those are aspirin, caffeine, methylene blue, thiamine, etc. Unsurprisingly, there are studies with each one of these substances for treating Alzheimers, and some of them worked so well in an animal mode that they are not in a human clinical trial.
 

Elephanto

Member
Joined
May 21, 2015
Messages
820
Giving blood/chelating iron could be part of the answer like that study Haidut mentionned. The researchers didn't even make the link between iron accumulation and glucose oxidation, but I think I've found it :

Iron upregulates P53
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808103/

Aluminium-induced oxidative damage to DNA may be involved in the neurodegeneration via increase in p53 expression
http://www.ncbi.nlm.nih.gov/pubmed/19464335

Inhibition of p53 activity improves insulin resistance, decreases proinflammatory cytokines
http://www.ncbi.nlm.nih.gov/pubmed/19718037
(hence why they call alzheimer "diabetes of the brain")

So it might not be the iron or aluminium that do neuronal damage, but the response by p53 inducing insulin resistance locally.
 

jyb

Member
Joined
Nov 9, 2012
Messages
2,771
Location
UK
jimmyquick said:
Remember the story of the women who fed her husband coconut oil because he had Alzheimer's who then drastically improved? I think I remember listing to a podcast with the women being interviewed on Dave Asprey's podcast and him telling her it was helping her husband only because the brain actually favors those type of saturated and MCT fats over glucose.

The brain likes occasional ketones, not fatty acids and not necessarily all day long. Here is an explanation of what fuels the brain likes, comparing ketones, lactate, glucose and free fatty acids: http://high-fat-nutrition.blogspot.co.uk/search/label/Neuron fuel and function

I don't think its true that the brain is like any other organ and just wants to max on glucose. Organs can be very different in how and what fuel they use preferentially.
 

pboy

Member
Joined
Jan 22, 2013
Messages
1,681
im pretty sure the body ultimately wants lipids and protein for structural and functional purposes, and it wants sugar not only for those also, but fuel. The fact it can use fat and protein as fuel is just a benefit...it doesn't appear to be ideal at all. Protein leaves toxic residues, and fat is incredibly slow to transport around compared to glucose, fat also has a hard time being eliminated from the body because its not readily water soluble.

Your brain uses sugar like anything else, like the guy above said, if you can use sugar anywhere you can pretty much use it everywhere, and it all has to do with a nutritious diet basically at the core. In a ratio wise you need enough vitamins and minerals to the carbohydrates you're consuming. Sounds simple and people might be like 'well then how do all these people have issues ect', imbalanced diet, and also...once you're sufficiently plugged up with whatever that stuff is that looks like fat and tension, it can take time to heal that for sugar to reach the finest channels in the body, even once your diet is optimized for sugar usage. A lot of ability to use sugar has to do with ability to breath also, which...not just in the literal sense, but in the metaphoric sense. If youre not able to breath...be present where you are and ok with it, like if any kind of stress, bad air quality, even simply people around you that make you feel uncomfortable, restrictive clothing, a situation that represses ability to express yourself...all of these things inhibit ability to fully max utilize sugar. Its about your brain sending signals of if the usage of sugar will be futile, met with hostility or knocked down some how, or if it will enhance you and possibly improve the area around you or bring joy to other people...thyroid goes hand and hand with this, its the throttle
 

tara

Member
Joined
Mar 29, 2014
Messages
10,295
My understanding too is that different tissues may have different fuel preferences - eg apparently muscles at rest like to burn fat, but when they are active they need sugar.
My understanding is that a well-functioning brain generally prefers sugar.

It also needs oxygen to efficiently oxidise sugar.
Oxygen supply is dependent on CO2. Tissues that produce CO2 get more O2 delivered to them.
So if a bit of the brain has a go-slow or stop event, it can reduce its production of CO2, and then it might not easily recover without intervention. I think that's Peat's explanation about why baking soda worked for a woman who was partially incapacitated by a stroke - it got a bit of CO2 into her general circulation, and thence into the vicinity of the affected brain region, and got enough oxygen delivered to it to get oxidation - and energy production - going again.

And then it also needs all the other co-factors too - eg. T3, vitamins, minerals.
 
Similar threads
Thread starter Title Forum Replies Date
Lokzo Creatine Exerts Same Effects As Ketamine In The Brain? Scientific Studies 2
yerrag Please... I'm wracking my brain... but pls. give me an instance our miltary actually defended its people. Political Talk, Alternative World Theories 10
E Brain Damage Reversed in Mice Scientific Studies 0
E Which Exact Brain Or Neurological Changes Create Specific Aspergers Behaviors? Autism 5
Hgreen56 Salt, Sugar, And Dietary Fat Trigger Opioids In The Brain Which Can Contribute To Overeating Diet 4
M Ways To Inhibit 5AR In The Brain Male Issues 19
L How Do You Encourage Facial Nerve Healing After Severe Brain Trauma? Miscellaneous Health Discussions 17
E SARS-CoV-2 Spike Proteins Disrupt The Blood-Brain Barrier, Potentially Raising Risk Of Neurological Scientific Studies 2
M Brain Supplement Recommendations For People With Serotonin Sensitivity Ask For Help or Advice 2
Doludolu "Ketones - The Primary Fuel Of The Brain And The Key Of Human Evolution" ; Connection With Babies Metabolism 14
M How To Treat Leaky Blood-brain-barrier If One Is Sensitive To Caffeine Pill? Ask For Help or Advice 3
D My Brain Is In Trouble And I Need Help Supplements, Pharmaceutical Drugs 24
E β-glucan Attenuates Cognitive Impairment Via The Gut-brain Axis In Diet-induced Obese Mice [10- 2020 Scientific Studies 0
TopGun1911 Massive Brain Fog After Taking Aspirin (500 Mg) Supplements, Pharmaceutical Drugs 14
B New Research Suggests The Conversion Of Testosterone To Estrogen In The Brain Is Crucial For Male Se Ask For Help or Advice 40
B My Scalp Looks Like A Brain! Ask For Help or Advice 17
haidut Alcohol Brain Damage Due To Iron Accumulation; Vitamin B1 To The Rescue Scientific Studies 3
Hans Are You Being Mind Controlled By Your Second Brain? Articles & Scientific Studies 8
C Mood/Quality Of Life, Brain Help Experiments 3
Marcine Study On Fructose Brain Effect Ask For Help or Advice 8
Mito Progesterone In The Brain: Hormone, Neurosteroid And Neuroprotectant Progesterone 0
haidut Food Emulsifiers And Endotoxin (LPS) Cause Brain Bleeding Scientific Studies 5
E Noise Disturbs The Brain's Compass Scientific Studies 0
A.R Progesterone Not Helpful For Brain Injury? Scientific Studies 13
milkboi What Characterizes Brain Fatigue And How To Combat It? Ask For Help or Advice 23
A Neanderthals Had Superior Sugar Transport To The Brain Ray Peat Topics 5
haidut Blocking PUFA Supply Halts Brain Cancer (glioblastoma) Scientific Studies 0
haidut SSRI Drugs Strikingly Toxic For Fetal Brain, May Cause Autism Scientific Studies 6
haidut Vitamin B3 Remarkably Therapeutic For Brain Cancer (glioblastoma) Scientific Studies 2
Kingpinguin Moderate Whisky With Meal Reduces Brain Tryptophan Beverages, Fruits, Sugars 9
A Brain Fog/sleepines After Coffee. Problems With Blood Flow/sulphur? Ask For Help or Advice 7
johnwester130 Ate Some Sourdough Bread = Brain Fog So Bad I Fell Asleep Diet, Recipes 2
D Constant Insatiable Hunger, Extreme Stress, And Brain Fog All For 7 Years Now Ask For Help or Advice 92
Such_Umami Brain Inflammation After Basketball And Fat Ask For Help or Advice 7
Lokzo Estrogen Up-regulates Androgen Receptors (AR) In The Brain Scientific Studies 5
michael94 Brain Glycine Levels Not Always Limited To Glycine Intake Meat, Organ Meat, Gelatin, Seafood 2
haidut Epilepsy, As A Result Of Brain Injury (TBI), Is Caused By Endotoxin Receptor (TLR4) Scientific Studies 3
Atma Return To The Brain Of Eden: Restoring The Connection Between Neurochemistry And Consciousness The Ray Peat Forum Lounge 5
Lokzo Riboflavin And Pyridoxine Restore Dopamine Levels And Reduce Oxidative Stress In Brain Of Rats Scientific Studies 0
haidut America’s Favorite Oil Causes Diabetes, Obesity, Autism, And Liver / Brain Disease Scientific Studies 0
haidut Emulsifiers Found In Most Commercial Foods Cause Brain Tumors, Hemorrhage, And Stroke Scientific Studies 2
W Diet And Supplements To Help Heal Mercury Damaged Brain? Mental Issues 33
GreekDemiGod Instant Brain Energy Boost From White Sugar Metabolism 4
L Soybean Oil Causes Genetic Changes In The Brain . Scientific Studies 1
Inaut Milk Is Brain Food For The Genius Dairy 55
Ras America's Most Widely Consumed Oil Causes Genetic Changes In The Brain Scientific Studies 8
haidut Blocking Serotonin, Adrenaline Treats Anxiety, Brain Damage Due To Alcohol "addiction" Scientific Studies 6
Frankdee20 Hard To Determine Brain Chemistry Ask For Help or Advice 12
Lokzo Colostrum Decreases Serotonin Production In Rat Brain Scientific Studies 3
Mauritio Birth Control Shrinks The Brain ! Scientific Studies 12

Similar threads

Top