meatbag
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"Based on RNA sequencing, we describe six groups of chemicals," Zylka said. "We found that chemicals within each group altered expression in a common manner. One of these groups of chemicals altered the levels of many of the same genes that are altered in the brains of people with autism or Alzheimer's disease."
Chemicals in this group included the pesticides rotenone, pyridaben, and fenpyroximate, and a new class of fungicides that includes pyraclostrobin, trifloxystrobin, fenamidone, and famoxadone. Azoxystrobin, fluoxastrobin, and kresoxim-methyl are also in this fungicide class.
Also, these chemicals caused an elevated expression of genes associated with inflammation in the nervous system. This so-called neuroinflammation is commonly seen in autism and neurodegenerative conditions.
Jeannie T. Lee, MD, PhD, professor of genetics at Harvard Medical School and Massachusetts General Hospital: " The work is timely and has wide-ranging implications not only for diseases like autism, Parkinson's, and cancer, but also for the health of future generations. I suspect that a number of these chemicals will turn out to have effects on transgenerational inheritance."
The use of all the fungicides in this group has increased dramatically over the past decade.
Zylka noted that conventionally grown leafy green vegetables such as lettuce, spinach, and kale have the highest levels of these fungicides. But due to each chemical's effectiveness at reducing fungal blights and rust, crop yields have increased and farmers are expanding their use of these chemicals to include many additional types of food crops.
"Virtually nothing is known about how these chemicals impact the developing or adult brain," Zylka said. "Yet these chemicals are being used at increasing levels on many of the foods we eat."
Link: Could a new class of fungicides play a role in autism, neurodegenerative diseases?
"the work of people like Harry Rubin has made it clear that functional changes in cells that are becoming cancerous destabilize the chromosomes and cause defects to appear in the genes, rather than the reverse."-Regeneration and degeneration - Types of inflammation change with aging
"The embryo's brain development is my favorite example of the ways genes interact with the environment. We might think of the "optimal brain development" of a person, or a rat, or a chicken, as something which is clearly limited by "the genes." But if rats are given a stimulating environment, each generation gets a slightly bigger, slightly more intelligent brain." -The problem of Alzheimer's disease as a clue to immortality Part 1
The use of extremely toxic pesticides has affected both the crops and the sensitivity of the human population to allergens.-Vegetables, etc.Who Defines Food?
Chemicals in this group included the pesticides rotenone, pyridaben, and fenpyroximate, and a new class of fungicides that includes pyraclostrobin, trifloxystrobin, fenamidone, and famoxadone. Azoxystrobin, fluoxastrobin, and kresoxim-methyl are also in this fungicide class.
Also, these chemicals caused an elevated expression of genes associated with inflammation in the nervous system. This so-called neuroinflammation is commonly seen in autism and neurodegenerative conditions.
Jeannie T. Lee, MD, PhD, professor of genetics at Harvard Medical School and Massachusetts General Hospital: " The work is timely and has wide-ranging implications not only for diseases like autism, Parkinson's, and cancer, but also for the health of future generations. I suspect that a number of these chemicals will turn out to have effects on transgenerational inheritance."
The use of all the fungicides in this group has increased dramatically over the past decade.
Zylka noted that conventionally grown leafy green vegetables such as lettuce, spinach, and kale have the highest levels of these fungicides. But due to each chemical's effectiveness at reducing fungal blights and rust, crop yields have increased and farmers are expanding their use of these chemicals to include many additional types of food crops.
"Virtually nothing is known about how these chemicals impact the developing or adult brain," Zylka said. "Yet these chemicals are being used at increasing levels on many of the foods we eat."
Link: Could a new class of fungicides play a role in autism, neurodegenerative diseases?
"the work of people like Harry Rubin has made it clear that functional changes in cells that are becoming cancerous destabilize the chromosomes and cause defects to appear in the genes, rather than the reverse."-Regeneration and degeneration - Types of inflammation change with aging
"The embryo's brain development is my favorite example of the ways genes interact with the environment. We might think of the "optimal brain development" of a person, or a rat, or a chicken, as something which is clearly limited by "the genes." But if rats are given a stimulating environment, each generation gets a slightly bigger, slightly more intelligent brain." -The problem of Alzheimer's disease as a clue to immortality Part 1
The use of extremely toxic pesticides has affected both the crops and the sensitivity of the human population to allergens.-Vegetables, etc.Who Defines Food?
