Has anyone tried boosting their AR activity while using topical finasteride? So you would have local DHT inhibition in the hair follicle but increased AR activity in other parts of the body?
I understand that topical fin still goes systematic but to a much lesser degree than oral fin.
What do people think? I already know that reducing AR activity will have an impact on key neurosteroids and so am not advocating that this should be reduced, but in this scenario if you keep overall AR activity stable, what issues can arise from fin? (Also just for the sake of comments, I understand that DHT is not the key driver of hairloss and that a cascade of events leads to dht being upregulated in the hair follicle due to inflamation of some kind)
E.g. If you block 30% of receptor activity but increase activity in the remaining active ones, what would be the costs
Tell me if i am being stupid here. Open to any thoughts
I understand that topical fin still goes systematic but to a much lesser degree than oral fin.
What do people think? I already know that reducing AR activity will have an impact on key neurosteroids and so am not advocating that this should be reduced, but in this scenario if you keep overall AR activity stable, what issues can arise from fin? (Also just for the sake of comments, I understand that DHT is not the key driver of hairloss and that a cascade of events leads to dht being upregulated in the hair follicle due to inflamation of some kind)
E.g. If you block 30% of receptor activity but increase activity in the remaining active ones, what would be the costs
Tell me if i am being stupid here. Open to any thoughts