Blood Test Results - Premature Ejaculation

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Me I got aroused in a moment
In a look
In a word
In a touch

But the remembrance of P.E.
makes me hate sex

Because sex for me in not joy
I cum in seconds
And after that
I just have intercourse to make my partner happy in bed
So it’s like cardio workout

After the first time I cum
The second time I got arouse
After 3 minutes
My penis shrink half size in length and width when I’m aroused
I can last 3 minutes

Cialis pycnogenol and citruline
Makes my penis more full and the cum more joyful

U said about the nmda

Do you think I should try l dopa?
I think you have to tame your 5-HT1A receptors.
SSRI can do this, but also the natural Ayurveda herb Ashwagandha can reduce its receptors via mRNA.
after a month of use you should see results.

The speed of ejaculation appears to be determined by 5-HT2C and 5-HT1A receptors. Stimulation of 5-HT2C receptors with non-selective 5-HT2C agonists delays ejaculation in male rats whereas stimulation of postsynaptic 5-HT1A receptors resulted in shorter ejaculation latency (Ahlenius et al 1981).
New agents in the treatment of premature ejaculation

Supplementation of 100mg/kg ashwagandha root to normal rats for up to eight weeks has been noted to reduce 5-HT1A serotonin signalling in response to agonists while increase sensitivity of 5-HT2 signalling.[126]

Ashwagandha: Scientific review on benefits, side effects, dosage, and more.
 
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R

RobbieT

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Interesting ideas.

This of course is counter to Peat's ideas, isn't it?

Desensitizing 5-ht1a, so lowering the receptors to increase the amount of serotonin, as you say much like an SSRI.
The ideas around here would be more agnosing the receptor to reduce serotonin and look to increase dopamine.
 
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Interesting ideas.

This of course is counter to Peat's ideas, isn't it?

Desensitizing 5-ht1a, so lowering the receptors to increase the amount of serotonin, as you say much like an SSRI.
The ideas around here would be more agnosing the receptor to reduce serotonin and look to increase dopamine.
That is not correct, peat warns against excess serotonin. You need serotonin and GABA to modulate brain processes.
So if that means increasing select serotonin receptors, nothing wrong with that.
But people can take things out of context. Probably because of some article stating "LSD is an serotonin antagonist," and so all serotonin in the brain is bad.
 
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Interesting ideas.

Desensitizing 5-ht1a, so lowering the receptors to increase the amount of serotonin, as you say much like an SSRI.
The ideas around here would be more agnosing the receptor to reduce serotonin and look to increase dopamine.

No, actually the opposite, slowing down the activity of serotonin on the post-synaptic 5-HT2C. it's confusing.
You don't want to use an agonist on this one pre-synaptic receptor, this leads to negative feedback and can lead to Premature Ejac.
 

Frankdee20

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..and so, when you look in the brain it is serotonin activity on 5-HT1A that, if overactive leads to shorter ejaculation latency / premature.
but stimulation of 5HT2C will delay ejaculation.

How or what can be used to hit 5ht1C ? You’re right though, I did read something about that receptor in the etiology of P E
 

Frankdee20

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@Frankdee20

I tried 5 htp 300 mg

One person in the past said 300 will make you last forever

I tried it it made me worse

When I eat more fruit and vegetables
Which all are high in sugar sodium magnesium and potassium
I feel I can last 10 more seconds

It seems what micheal said that some of us run on stress hormones

Even baking soda makes me last little longer

But I wanna control my ejaculation

I don’t want to be controlled by ejaculation

I really am interested on how to reverse our state of shiiiit

Wow, that’s a high dose of 5htp. I will never touch that stuff again, but I recall 18 years ago using it, severe stress reactions. Made my PE worse. All that is doing is creating more Serotonin and we don’t know which receptors are getting more of it. I think this is a 5ht receptor problem, not Serotonin global level problem
 

Frankdee20

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Perhaps, tense pelvic floor muscles play a role here too. Magnesium can relax muscles, but I would think bigger muscles get magnesium first. Sometimes it helps, I don’t know
 

Frankdee20

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I tried the mg
It didn’t help honestly
I got days I take 2000 mg mg

I wonder if it’s just a reflex or nerves that are just shot down there. Does anyone ever report it diminishing eventually ? I didn’t always have this, and honestly, there’s times when it’s not even an issue
 

Frankdee20

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I’ve definitely had ejaculatory angedonia though for 20 years, ever since 5htp messed me up.
 
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How or what can be used to hit 5ht2C ? You’re right though, I did read something about that receptor in the etiology of P E
I dont know exactly, some SSRI and there are drugs in the making.
I’ve definitely had ejaculatory angedonia though for 20 years, ever since 5htp messed me up.
Excess serotonin / SSRI flooding the synapse will downregulate the 5-ht1A receptors and could lead to dysfunctions like that.
You can upregulate 5-HT1 and 5HT2 with St Johns Wort.
"At a receptor level, chronic treatment with hypericum downregulates beta1-adrenoceptor, upregulates post-synaptic 5-HT1A receptors and 5-HT2 receptors."
Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. - PubMed - NCBI
edit Selegiline should work also

-And Rhodiola

Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. - PubMed - NCBI

3 -and MACA
An improvement in SSRI induced sexual dysfunction has been noted with Maca supplementation

www.ncbi.nlm.nih.gov/pubmed/18801111
 
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Frankdee20

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I dont know exactly, some SSRI and there are drugs in the making.

Excess serotonin / SSRI flooding the synapse will downregulate the 5-ht1A receptors and could lead to dysfunctions like that.
You can upregulate 5-HT1 and 5HT2 with St Johns Wort.
"At a receptor level, chronic treatment with hypericum downregulates beta1-adrenoceptor, upregulates post-synaptic 5-HT1A receptors and 5-HT2 receptors."
Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. - PubMed - NCBI
edit Selegiline should work also

-And Rhodiola

Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. - PubMed - NCBI

3 -and MACA
An improvement in SSRI induced sexual dysfunction has been noted with Maca supplementation

www.ncbi.nlm.nih.gov/pubmed/18801111

See I’ve always wanted to try SJW, but upregulating 5ht2A isn’t great for depression
 
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See I’ve always wanted to try SJW, but upregulating 5ht2A isn’t great for depression
Using SJW right now, second month, no problem with it, tends to prefer upping dopamine, boost my libido, and regulating the rest. I take 2x300mg in the morning. Helps against depression, makes me more assertive. I'm recovering from SSRI and heavy MDMA use myself.

edit: only thing is, when drinking coffee with it I get aggressive/anxiety, so I drink choco or tea.
 
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Frankdee20

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Using SJW right now, second month, no problem with it, tends to prefer upping dopamine, boost my libido, and regulating the rest. I take 2x300mg in the morning. Helps against depression, makes me more assertive. I'm recovering from SSRI and heavy MDMA use myself.

edit: only thing is, when drinking coffee with it I get aggressive/anxiety, so I drink choco or tea.

SJW is definitely unique in that many neurotransmitter systems are effected via different mechanisms.
 

Frankdee20

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Do you worry about withdrawal effects upon stopping SJW ?
 

Frankdee20

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Buspirone is always the one existing drug that effects that 5ht1a on both sides mentioned in PSSD circles.

But wouldn’t the agonist property cause eventual down regulation ?
 
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Buspirone is always the one existing drug that effects that 5ht1a on both sides mentioned in PSSD circles.

But wouldn’t the agonist property cause eventual down regulation ?
-I think it is a partional agonist that does not downregulate 5HT1A if I read this right.

edit: it could downregulates central 5-HT2 post synaptic receptors and could be sedative.
 
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Frankdee20

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I think it’s partial on one particular side and a full on the other
 

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