Blood Glucose Varies Widely In Healthy People, Can Reach Even Diabetic Levels

haidut

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I noticed over the years that many of the people diagnosed with pre-diabetes or diabetes II have received their diagnosis based on a single fasting blood test. The use HbA1C is not as widespread among PCP, despite what mainstream media claims. About half of the cases of newly diagnose pre-diabetes and diabetes had their tests redone in a week and the results were normal. However, their doctor told them they have to keep taking their metformin because once made the diagnosis is next to impossible to reverse.
The new study below did what every doctor should do before making such diagnoses - they performed continuous blood glucose monitoring for a period of 2-4 weeks. The glucose measuring device took readings every 5 minutes. The study found that blood glucose is highly variable across different people. In fact, 25% presented what the study calls "severe" glucose variability, with 15% having variations that fluctuated between normal and pre-diabetic levels, and 2% had variations that reached the diabetic levels and then went back to normal. Given that 25%+ of people had variations that put them in the pathological range as based on a single test, this suggests that many of the people officially diagnosed with pre-diabetes or diabetes may be wrongly diagnosed and pushed into unnecessary use of prescription drugs.

Glucotypes reveal new patterns of glucose dysregulation
"...In this study, we recorded almost 500,000 measurements from 57 participants. We observed a considerable amount of intra- and interpersonal variability in glucose measurements. Spectral clustering revealed 3 glucotypes of increasing variability (low, moderate, and severe)—each also characterized by increasing mean glucose—that explained 73% of the observed variance. The fraction of time spent in low and severe variability patterns correlated with standard measures of glycemia associated with diabetes risk. However, within traditional classification categories based on fasting and 2-hour glucose (OGTT) or HbA1c, all three glucotype patterns could be observed, indicating that current classification schemes are overly simplistic. Of great interest is the possibility that identification of those with severe glycemic variability within the group of normoglycemic or prediabetic individuals would enhance prediction of risk of progression to diabetes. Indeed, severe glucose variability was present in 25% of normoglycemic individuals, and within this subgroup, glucose reached prediabetic or diabetic glucose levels 15% and 2% of the time, respectively. We speculate that an increase in glucose variability might thus precede the currently used measures defining abnormal glucose levels and thus represent an even earlier stage of “prediabetes.” Longer-term studies are warranted to define whether identification of a “severe glucotype” via CGM has greater predictive value for development of type 2 diabetes than do traditional tests. The fact that CGM obtains glucose excursions in a real-living situation as compared to the artificial glucose tolerance test may be of added value in this regard."
 

Tenglish

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This is exactly in line with both my professional data categorization work and personal N=1 experiments with a continuous glucometer which just happen to be overlapping. What the more senior researchers talk about following such findings (reversion to normal HbA1C classifications from single point testing), unfortunately; is the inappropriateness of testing more than a specific target population. My intuition is that we need better theory and better tests. IMO that is just keeping the data fidelity low to prevent up-ending the theory. With my Freestyle glucometer I was surprised to see a number of spikes and usually related to stress vice meal composition...meaning also if you are stressed to see a doctor you will likely be inappropriately categorized.
 

vulture

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Sep 1, 2017
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Great posts guys.
Read this after the liver cirrhosis treatment with T and niacin...It's sad how many people's lives might end up ruined by mediocrecy and commercial interests.
I was diagnosed with hypertension after a surgery that went wrong, I discussed with my MD because in the middle of a 3 day fasting my BP dropped a lot, I stopped taking medication and after the 3 days started eating and BP was fine, only higher readings at her desk, and she didn't wanted to take me off medication, I went to another MD and asked to carry a device to monitor my BP all day, it was normal, never toke BP medications, ever.
 

Peater Piper

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Mar 18, 2016
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I think the question is whether or not those people with large variations in glucose levels are actually healthy. I absolutely agree that one abnormal fasting level is not sufficient for diagnosing diabetes, but if a patient is experiencing large spikes in glucose after meals, even with a normal HbA1c, then they're headed for dangerous territory imo. People tested over decades who had the lowest risk of diabetes had ridiculous glucose control, rarely exceeding 120 mg/dl even after high carb meals.
 
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