- Aug 31, 2015
Alveolar stretch imposed by MV did not only induce de novo synthesis of adhesion molecules in the lung but also in organs distal to the lung, like liver and kidney. No activation was observed in the brain. In addition, we demonstrated elevated cytokine and chemokine expression in pulmonary, hepatic and renal tissue after MV which was accompanied by enhanced recruitment of granulocytes to these organs. Our data implicate that MV causes endothelial activation and inflammation in mice without pre-existing pulmonary injury, both in the lung and distal organs.
Thanks for the find.
Discussion & conclusionBased on the literature and clinical observation of mysterious clots reported in the COVID-19 patients, expression of ACE2 in the endothelium of blood vessels, blood clotting pathways, interaction of the SARS-CoV-2 spike protein with host ACE2, the pathogenesis of SARS-CoV-2, and the role of ACE2 in RAS, we can hypothesize and end with the conclusion that the mysterious clots reported in the COVID-19 patients may be due to the binding of the spike protein of SARS-CoV-2 with the ACE2 receptor expressed in the endothelial cells of blood vessels which may cause, vasoconstriction and activation of the intrinsic pathway of coagulation and eventually results in the formation of blood clots.
Makowski, who recently published his hypothesis in the journal Viruses, believes the spike protein found on the surface of the virus might mimic proteins that regulate blood vessels and control the formation of blood clots, which could explain many of the non-respiratory complications of COVID-19.Thanks for the find.
Might this explain blood clots post injectus horribillis (astrazeneca) when the spike protein spikes and bind to ace2 receptor?
If not viral infection, what else could be causing injury to distant organs associated with COVID-19?
Yes, thanks!Read post #3. It's been known for decades.
When hospital patients are placed on a mechanical ventilator for days at a time, their lungs react to the pressure with an out-of-control immune response. Researchers have discovered potential drug targets that might reduce the resulting inflammation.www.sciencedaily.com
Could Spike Protein in Moderna, Pfizer Vaccines Cause Blood Clots, Brain Inflammation and Heart Attacks? • Children's Health DefenseDr. J. Patrick Whelan, a pediatric rheumatologist, warned the FDA in December that mRNA vaccines could cause microvascular injury to the brain, heart, liver and kidneys in ways not assessed in safety trials.childrenshealthdefense.org
In a study of 18 COVID-19 patients with neurological symptoms who died in hospitals last April, Mukerji and colleagues found very low levels of viral RNA — the source of which is a mystery — in only five of the patient brains. Because the low RNA concentration “seems out of proportion to the profound deficits that people are experiencing,” Mukerji said, “I’d be extremely surprised [if] the majority of cases where people are having neurological symptoms are due to direct viral invasion.”
Can you share that?I also made a short introduction to the Zeta Potential that I handed out to physicians that treated my elder brother, who died from massive strokes from an 11-hour operation in 2018, where he also suffered a lung embolism, his heart set out and he went into a coma. Probably also from blood transfusions.
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