General Orange
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The spice black pepper and white pepper and it's extract Piperine - the bioavailability booster - has serotonergic effects, increasing its synthesis or inhibiting the reuptake of serotonin.
Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative. - PubMed - NCBI
Abstract
Piperine and two of its derivatives, antiepilepsirine (AE or 3,4-methylendioxycynnamoylpiperine) and compound 7448 (N-isopropyl 3 (4 chloro-phenyl) propenoylamide) are very effective in stimulating serotonin (5HT) synthesis. AE raises the ratio of free-to-bound tryptophan (TP) in plasma and induces a long-lasting increase of this aminoacid in brain. At the same time in striatum and limbic area it causes a lasting increase in 5 hydroxyindolacetic acid (5HIAA) a 5HT metabolite and to a lesser extent, an increase in the levels of the monoamine itself. Together with this action on 5HT metabolism we found that AE caused release of 3H-5HT from an in vitro synaptosomal preparation. It thus appears that piperine and its derivatives AE and compound 7148 affect the central serotonergic system.
It is a shame, coz it also is thyrogenic:
In animals fed a high-fat diet, piperine improved levels of T3, T4, and TSH (12; 15).
Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative. - PubMed - NCBI
Abstract
Piperine and two of its derivatives, antiepilepsirine (AE or 3,4-methylendioxycynnamoylpiperine) and compound 7448 (N-isopropyl 3 (4 chloro-phenyl) propenoylamide) are very effective in stimulating serotonin (5HT) synthesis. AE raises the ratio of free-to-bound tryptophan (TP) in plasma and induces a long-lasting increase of this aminoacid in brain. At the same time in striatum and limbic area it causes a lasting increase in 5 hydroxyindolacetic acid (5HIAA) a 5HT metabolite and to a lesser extent, an increase in the levels of the monoamine itself. Together with this action on 5HT metabolism we found that AE caused release of 3H-5HT from an in vitro synaptosomal preparation. It thus appears that piperine and its derivatives AE and compound 7148 affect the central serotonergic system.
It is a shame, coz it also is thyrogenic:
In animals fed a high-fat diet, piperine improved levels of T3, T4, and TSH (12; 15).
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