Sativa
Member
- Joined
- May 17, 2018
- Messages
- 400
Don't forget Kava Kava! - works via GABA-B iirc, also contains a weak yet notable cannabinoid - Yangonin, active at the CB1 'receptor'.
I had some of my Kava 84% Kavalactone extract paste earlier... alongside Magnesium, and some homemade Sodium Salicylate...
Kava contributes calming via GABA, it also upregulates the GABA system, implying it enhances it's sensitivity. It has mild Cannabinoid effects also. (progesterone also works via GABA!)
Mg contributes potent glutamate lowering effect - aka a cushioning effect (via NMDA 'antagonism')
NaSalicylate lowers cortisol & estrogen (anti-aromatase) & inhibits the COX enzyme.
Theanine is another interesting & useful substance, with potential.
Theanine is a dual GABAergic and NMDA antagonist.
Magnolia Bark is another very interesting one - it not only potentiates GABA but also has significant calming cannabinoid activity!
re progesterone & GABA:
All in all, this lays the foundation for a super-combination that mimics aspects of progesterone, amongst other things...
I had some of my Kava 84% Kavalactone extract paste earlier... alongside Magnesium, and some homemade Sodium Salicylate...
Kava contributes calming via GABA, it also upregulates the GABA system, implying it enhances it's sensitivity. It has mild Cannabinoid effects also. (progesterone also works via GABA!)
Mg contributes potent glutamate lowering effect - aka a cushioning effect (via NMDA 'antagonism')
NaSalicylate lowers cortisol & estrogen (anti-aromatase) & inhibits the COX enzyme.
Almost anything Peaty will tend to shift the balance of neurotransmitters to GABA and away from Glutamate. Glutamate being the opposite of GABA and causing anxiety and seizures, while GABA promotes relaxation and calmness.
Increasing estrogen exposure will lower GABA and increase Glutamate.
Theanine is another interesting & useful substance, with potential.
Theanine is a dual GABAergic and NMDA antagonist.
motivation, pro-social behaviour - this is apparently what GABA-B upregulation feels like. Interestingly, serotonin causes the same feelings like this: serotonin ---> 5-HT1A ---> GABA release ---> GABA-B activation.
This method of enhancing/increasing the GABA-B system via 'upregulation' is sort of a sustainable indirect way of increasing it's 'baseline state'.Yeah I wouldn't use phenibut anymore, I only use theanine.
Theanine gives the same effect as phenibut, but instead of through agonism it's through antagonism so it can be taken every day without tolerance.
Theanine blocks mGlu1, which is coupled with GABA-B.
So by antagonizing and upregulating mGlu1, it upregulates GABA-B.
...
The GABA-B upregulation happens after theanine wears off.
Magnolia Bark is another very interesting one - it not only potentiates GABA but also has significant calming cannabinoid activity!
re progesterone & GABA:
I did not know that Progesterone raises GABA-B instead of GABA-A. I do know that a metabolite of progesterone called allopregnanolone does raise GABA-A. Also androsterone raises GABA-A.
All in all, this lays the foundation for a super-combination that mimics aspects of progesterone, amongst other things...
- anti-catabolic == pro-anabolic
- pro-androgenic
- anti-cortisol
- anti-estrogen (anti-aromatase, boost liver detox)
- anti-glutamate (NMDA antagonism)
- pro-GABA (either via upregulation or direct activation aka agonism)
...palmitic acid increased pregnenolone, DHEA in the adrenals, while at the same time decreasing cortisol synthesis.
...
...ingesting larger doses palmitic acid from food may be more effective for androgen boost.
So, butter, cheese, milk, meat, cocoa fat, coconut oil etc are all good sources.
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