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Black Pepper Piper Nigrum Increases Serotonin Synthesis

Discussion in 'Scientific Studies' started by General Orange, Nov 6, 2018.

  1. General Orange

    General Orange Member

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    The spice black pepper and white pepper and it's extract Piperine - the bioavailability booster - has serotonergic effects, increasing its synthesis or inhibiting the reuptake of serotonin.

    Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative. - PubMed - NCBI

    Abstract
    Piperine and two of its derivatives, antiepilepsirine (AE or 3,4-methylendioxycynnamoylpiperine) and compound 7448 (N-isopropyl 3 (4 chloro-phenyl) propenoylamide) are very effective in stimulating serotonin (5HT) synthesis. AE raises the ratio of free-to-bound tryptophan (TP) in plasma and induces a long-lasting increase of this aminoacid in brain. At the same time in striatum and limbic area it causes a lasting increase in 5 hydroxyindolacetic acid (5HIAA) a 5HT metabolite and to a lesser extent, an increase in the levels of the monoamine itself. Together with this action on 5HT metabolism we found that AE caused release of 3H-5HT from an in vitro synaptosomal preparation. It thus appears that piperine and its derivatives AE and compound 7148 affect the central serotonergic system.

    It is a shame, coz it also is thyrogenic:

    In animals fed a high-fat diet, piperine improved levels of T3, T4, and TSH (12; 15).
     
  2. xeliex

    xeliex Member

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    Thank you, looking into the research to weigh the risks vs benefits
     
  3. Lokzo

    Lokzo Member

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    Excellent findings. Thank you.
     
  4. OP
    General Orange

    General Orange Member

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  5. akgrrrl

    akgrrrl Member

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    3 months now I have just been FLYING HIGH in energy after a morning cup of boiling water over creamed coconut, turmeric, cinnamon, ginger, sugar and black pepper oil. Jeezo-Peat , Orange, didja have ta go and let the air outta my ride? Dang it.
     
  6. OP
    General Orange

    General Orange Member

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    No worries, black pepper oil does not contain the Piperine.
     
  7. OP
    General Orange

    General Orange Member

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    But what's interesting about the pepper oil is, smelling it's fragrance seems to be exiting and it is measured that it increase adrenaline:

    Effects of fragrance inhalation on sympathetic activity in normal adults. - PubMed - NCBI
    "We investigated the effects of fragrance inhalation on sympathetic activity in normal adult subjects using both power spectral analysis of blood pressure fluctuations and measurement of plasma catecholamine levels.
    Fragrance inhalation of essential oils, such as pepper oil, estragon oil, fennel oil or grapefruit oil, resulted in 1.5- to 2.5-fold increase in relative sympathetic activity, representing low frequency amplitude of systolic blood pressure (SBP-LF amplitude), compared with inhalation of an odorless solvent, triethyl citrate (P<0.05, each).
    In contrast, fragrance inhalation of rose oil or patchouli oil caused a 40% decrease in relative sympathetic activity (P<0.01, each).
    Fragrance inhalation of pepper oil induced a 1.7-fold increase in plasma adrenaline concentration compared with the resting state (P = 0.06), while fragrance inhalation of rose oil caused a 30% decrease in adrenaline concentration (P<0.01).
    Our results indicate that fragrance inhalation of essential oils may modulate sympathetic activity in normal adults."

    - maybe that's why you are flying so high ?
     
  8. akgrrrl

    akgrrrl Member

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    Aye...it could be---the whole drink is just vibrant with fat and sugar and spice. And I do love the smell of the pepper a lot. When the hot water hits it in the cup and it wafts up, I just know it is amplifying the curcuminoids in the turmeric, and the hot water activates the cinnamon and ginger and I get a nice warm rush soon after a halfcup ....
     
  9. Captain_Coconut

    Captain_Coconut Member

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    Bump. Wondering how bad taking 10mg piperine daily would be in terms of increasing serotonin, vs improvement of gaba and dopamine and improved bioavailability of most supplements I take.
     
  10. cdg

    cdg Member

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    How much of each are you using? Thanks
     
  11. akgrrrl

    akgrrrl Member

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    I blended in equal amounts, Ceylon cinnamon, organic powdered ginger, and the best turmeric I could find. I put a rounded tsp in a heated cup with the boiling water,then add Aunt Patties creamed coconut DELICIOUS, and a big spoon of raw honey. The pepper oil I stir in last, 3 drops. Of course the weight of the powders make them sink, so stirring is necessary while consuming
     
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