paymanz

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Biotin augments acetyl CoA carboxylase 2 gene expression in the hypothalamus, leading to the suppression of food intake in mice. - PubMed - NCBI

It is known that biotin prevents the development of diabetes by increasing the functions of pancreatic beta-cells and improving insulin sensitivity in the periphery. However, its anti-obesity effects such as anorectic effects remain to be clarified. Acetyl CoA carboxylase (ACC), a biotin-dependent enzyme, has two isoforms (ACC1 and ACC2) and serves to catalyze the reaction of acetyl CoA to malonyl CoA. In the hypothalamus, ACC2 increases the production of malonyl CoA, which acts as a satiety signal. In this study, we investigated whether biotin increases the gene expression of ACC2 in the hypothalamus and suppresses food intake in mice administered excessive biotin. Food intake was significantly decreased by biotin, but plasma regulators of appetite, including glucose, ghrelin, and leptin, were not affected. On the other hand, biotin notably accumulated in the hypothalamus and enhanced ACC2 gene expression there, but it did not change the gene expression of ACC1, malonyl CoA decarboxylase (a malonyl CoA-degrading enzyme), and AMP-activated protein kinase α-2 (an ACC-inhibitory enzyme). These findings strongly suggest that biotin potentiates the suppression of appetite by upregulating ACC2 gene expression in the hypothalamus. This effect of biotin may contribute to the prevention of diabetes by biotin treatment.
 

Rand56

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Aug 7, 2013
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I'm giving high dose biotin a whirl, and I can also say my appetite has lessened some. Being all the good things I have read about biotin on here, I decided to give it a shot, despite the fact that when I previously tried it in the past, I would get acne breakouts if I pushed it any higher than 1mg per day. Strangely, and fortunately, when I started again, I went straight to 15mg's per day about 1.5 weeks ago, and now doing 20mg's per day. Since day one I have not had any acne breakouts. Seems odd, but I'm not complaining. I started up with Haidut's TocoVit at about the same time, so I don't know if the quality of his E has helped keep the acne at bay, possibly so.
 
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