aguilaroja
Member
- Joined
- Jul 24, 2013
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High dose biotin supplements can falsely elevate TSH or other thyroid lab tests.
@Koveras discussed this in March, but maybe a separate post can emphasize the concern.
Confusing Blood Tests - High FT3 And FT4 And High TSH
This is ONLY a caution about interpreting thyroid LAB tests with recent high biotin intake. There is no evidence, on brief literature review, that boosting biotin intake damages real-world thyroid function.
Supplementary biotin, and potential benefits, has been mentioned by @haidut, @paymanz and others. Dr. Peat has mentioned biotin in some essays:
Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
“Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis (Marshall, et al., 1976).”
Biotin is being used for multiple sclerosis relief, and for other matters.
For those, and their doctors, using thyroid lab tests for decision making, it may be better to stop added biotin in the short term before testing.
A Single 10 mg Oral Dose of Biotin Interferes with Thyroid Function Tests. - PubMed - NCBI
Biotin Interference in Thyroid Panel Assays With Biotinylated Components. - PubMed - NCBI
High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference. - PubMed - NCBI
Biotin interferes with free thyroid hormone and thyroglobulin, but not TSH measurements using Beckman-Access immunoassays. - PubMed - NCBI
Biotin treatment causing erroneous immunoassay results: A word of caution for clinicians. - PubMed - NCBI
https://www.jstage.jst.go.jp/article/ddt/10/6/10_2016.01074/_pdf
HIGH-DOSE BIOTIN TREATMENT FOR SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS MAY INTERFERE WITH THYROID ASSAYS
A caution regarding high-dose biotin therapy: misdiagnosis of hyperthyroidism in euthyroid patients
Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature. - PubMed - NCBI
Misdiagnosis of Graves' Disease with Apparent Severe Hyperthyroidism in a Patient Taking Biotin Megadoses. - PubMed - NCBI
@Koveras discussed this in March, but maybe a separate post can emphasize the concern.
Confusing Blood Tests - High FT3 And FT4 And High TSH
This is ONLY a caution about interpreting thyroid LAB tests with recent high biotin intake. There is no evidence, on brief literature review, that boosting biotin intake damages real-world thyroid function.
Supplementary biotin, and potential benefits, has been mentioned by @haidut, @paymanz and others. Dr. Peat has mentioned biotin in some essays:
Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
“Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis (Marshall, et al., 1976).”
Biotin is being used for multiple sclerosis relief, and for other matters.
For those, and their doctors, using thyroid lab tests for decision making, it may be better to stop added biotin in the short term before testing.
A Single 10 mg Oral Dose of Biotin Interferes with Thyroid Function Tests. - PubMed - NCBI
Biotin Interference in Thyroid Panel Assays With Biotinylated Components. - PubMed - NCBI
High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference. - PubMed - NCBI
Biotin interferes with free thyroid hormone and thyroglobulin, but not TSH measurements using Beckman-Access immunoassays. - PubMed - NCBI
Biotin treatment causing erroneous immunoassay results: A word of caution for clinicians. - PubMed - NCBI
https://www.jstage.jst.go.jp/article/ddt/10/6/10_2016.01074/_pdf
HIGH-DOSE BIOTIN TREATMENT FOR SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS MAY INTERFERE WITH THYROID ASSAYS
A caution regarding high-dose biotin therapy: misdiagnosis of hyperthyroidism in euthyroid patients
Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature. - PubMed - NCBI
Misdiagnosis of Graves' Disease with Apparent Severe Hyperthyroidism in a Patient Taking Biotin Megadoses. - PubMed - NCBI
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