LeeLemonoil
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- Joined
- Sep 24, 2016
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Pfizer–BioNTech COVID-19 vaccine - Wikipedia
en.wikipedia.org
It does not look too shady. The lipid-formulation is hard to verdict on.
It seems the only modMRNA used is n-methyl-pseudouridine.
Pseudouridine is widely used in genetic research, that one is something different I guess.
I have one problem with this synthetic nucleoside though. It is built into the active to prevent detection of humaoral defense/TLRs. That's the entire purpose of the tech allrigth to increase duration of the mRNA in cytosol to stimulate enough antigen-production from the ribosomes.
But physiological mRNA gets degraded at some point. In the P-bodies of the cytosol.
Some nucleosides can even be salvaged and icorporated into new mRNA or stored and reactivated.
So what happens with the synthetic nucleosid? If it can evade immune system, can it also evade the mechanisms that degrade mRNA in P-bodies? Who knows anything about that?
Could that synthetic mRNA be reused and built into other mRNA and thus alter protein synthesis where it was not meant to?
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