Bifonazole, otc anti fungal, strong aromatase inhibitor, anti histamine, anti inflammatory

Michael Mohn

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Bifonazole is an OTC anti fungal medication that has a strong aromatase inhibition.
https://www.sciencedirect.com/.../pii/S0300483X05005366...
https://www.sciencedirect.com/.../medici.../antifungal-agent
bifonazole has also been shown to inhibit calmodulin a protein integral to prostaglandin synthesis and histamine release from mast cells. Elevated levels of calmodulin have been demonstrated in psoriatic plaques.
Aromatase inhibition is similar to letrozole in vitro Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC–MS/MS method for the analysis of estradiol product formation
 
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Michael Mohn

Michael Mohn

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Dec 7, 2019
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Germany
Almost all -azole drugs (anti-fungals) have aromatase inhibiting property.
True
but I haven't found anything about Bifonacole's toxicity and being otc in Germany must mean toxicity is pretty low. Most aromatase inhibitors are prescription only here.
 
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Michael Mohn

Michael Mohn

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Messages
879
Location
Germany
In a recent paper by Taha, et al., the researchers identified the imidazole-based antifungal, Bifonazole, and characterised its activity against SARS-CoV-2...

Following screening of 1,200 compounds, Bifonazole showed the most promise and was a potent competitive inhibitor of SARS-CoV-2 S RBD-ACE2 interactions
 

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