Best Dose, Frequency, And Duration For A Course Of Tetracycline

Pointless

Member
Joined
Apr 13, 2016
Messages
945
I tried ~125 mg of tetracycline last night. I'm noticing an improvement in my complexion, sleeping better, less bloating, more energy, increased body temperature, decreased white coating on tongue, but also sensitive gut, increased bowel movements, and hemorrhoids. I also have a metallic taste in my mouth which is an ordinary side effect. The negative effects could be from a cortisol reduction.

I've done a lot of reading on antibiotics here on the forum, but it seems like it's hit or miss for a lot of people. Some people get permanent results from one course, other people temporary results, other people nothing, still others nothing but side effects. I was wondering if this could be related to dose or duration of the course.

I know that Peat generally recommends smallish doses of antiobiotics, but I was wondering if anyone has any opinions on dosing tetracycline? Would very small doses like 20 mg or so cause antibiotic resistance with a net negative to gut health long-term?
 

Sucrates

Member
Joined
Jul 20, 2014
Messages
619
Up to 5omg doesn't create resistance. I'm not 100% sure if that's with doxy, tetra or both, I think both, but you should check.. Maximum suppression of inflammatory cytokines occur at 20-40mg. Tetracyclines suppress respiration in a dose dependent manner. So it depends on your goals, if gut related will depend on flora, pretty unpredictable. I emailed RP about the effects on respiration and he replied that the prescribed doses are perhaps too high.

Contents of a text file I have on the subject, I was interested in migraine/headache.

------
https://www.hindawi.com/journals/mi/2015/329418/
Literature data indicate that the high doxycycline doses (100–200 mg/day) used to treat rosacea correspond to a plasma concentration of 1.5–3 mg/μL, 2-3 hours after oral intake.

From that, we extrapolated the (20–40 mg) oral assumption.

http://www.jaad.org/article/S0190-9622(06)04043-6/abstract

Doxycycline 40 mg Capsules (30 mg Immediate-Release/10 mg Delayed-Release Beads)

Effects of Subantimicrobial-Dose Doxycycline in the Treatment of Moderate Acne

SAGE Journals: Your gateway to world-class journal research

http://vivo.med.cornell.edu/display/pubid74949110283

http://moscow.sci-hub.bz/dc4680d1e83dead83e4f57125acbbf30/[email protected]

http://onlinelibrary.wiley.com/doi/...ionid=9105607FC1AB2E88935043D06E1B3AEE.f02t01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073587/


Based on the non-antimicrobial, anti-inflammatory properties of tetracyclines, a host-modulatory agent comprising a subantimicrobial dose of doxycycline was developed (SDD), as a safe and effective adjunct to conventional non-surgical root surface debridement to treat chronic periodontitis. It has proved to be safe for use at 20 mg b.d for at least 3 months and up to 24 months in randomized placebo controlled clinical trials. It is an approved adjunct in its capacity as an MMP inhibitor of plaque biofilm-induced degradation of tooth-supporting periodontal structures of the dentition. Doxycycline is preferred as a more potent inhibitor of MMPs than tetracyclines. It is safer than minocycline with superior pharmacokinetics which favor improved patient compliance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631686/

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research
https://www.ncbi.nlm.nih.gov/pubmed/23741339

Doxycycline alters metabolism and proliferation of human cell lines.
Here, we report that in human cell lines, commonly used concentrations of doxycycline change gene expression patterns and concomitantly shift metabolism towards a more glycolytic phenotype, evidenced by increased lactate secretion and reduced oxygen consumption. We also show that these concentrations are sufficient to slow proliferation. These findings suggest that researchers using doxycycline in inducible expression systems should design appropriate controls to account for potential confounding effects of the drug on cellular metabolism.”

theoretical doxycycline blood concentrations of 0.3 and 0.6 mg/μL obtained 3 hours after low doses might result in 15% change in oxygen(down) and lactate (up)

https://www.ncbi.nlm.nih.gov/pubmed/23741339


https://raypeatforum.com/community/...otics-inhibit-mitochondrial-respiration.6151/
 

Sucrates

Member
Joined
Jul 20, 2014
Messages
619
Up to 5omg doesn't create resistance. I'm not 100% sure if that's with doxy, tetra or both, I think both, but you should check.. Maximum suppression of inflammatory cytokines occur at 20-40mg. Tetracyclines suppress respiration in a dose dependent manner. So it depends on your goals, if gut related will depend on flora, pretty unpredictable. I emailed RP about the effects on respiration and he replied that the prescribed doses are perhaps too high.

Contents of a text file I have on the subject, I was interested in migraine/headache.

------
https://www.hindawi.com/journals/mi/2015/329418/
Literature data indicate that the high doxycycline doses (100–200 mg/day) used to treat rosacea correspond to a plasma concentration of 1.5–3 mg/μL, 2-3 hours after oral intake.

From that, we extrapolated the (20–40 mg) oral assumption.

http://www.jaad.org/article/S0190-9622(06)04043-6/abstract

Doxycycline 40 mg Capsules (30 mg Immediate-Release/10 mg Delayed-Release Beads)

Effects of Subantimicrobial-Dose Doxycycline in the Treatment of Moderate Acne

SAGE Journals: Your gateway to world-class journal research

http://vivo.med.cornell.edu/display/pubid74949110283

http://moscow.sci-hub.bz/dc4680d1e83dead83e4f57125acbbf30/[email protected]

http://onlinelibrary.wiley.com/doi/...ionid=9105607FC1AB2E88935043D06E1B3AEE.f02t01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073587/


Based on the non-antimicrobial, anti-inflammatory properties of tetracyclines, a host-modulatory agent comprising a subantimicrobial dose of doxycycline was developed (SDD), as a safe and effective adjunct to conventional non-surgical root surface debridement to treat chronic periodontitis. It has proved to be safe for use at 20 mg b.d for at least 3 months and up to 24 months in randomized placebo controlled clinical trials. It is an approved adjunct in its capacity as an MMP inhibitor of plaque biofilm-induced degradation of tooth-supporting periodontal structures of the dentition. Doxycycline is preferred as a more potent inhibitor of MMPs than tetracyclines. It is safer than minocycline with superior pharmacokinetics which favor improved patient compliance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631686/

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research
https://www.ncbi.nlm.nih.gov/pubmed/23741339

Doxycycline alters metabolism and proliferation of human cell lines.
Here, we report that in human cell lines, commonly used concentrations of doxycycline change gene expression patterns and concomitantly shift metabolism towards a more glycolytic phenotype, evidenced by increased lactate secretion and reduced oxygen consumption. We also show that these concentrations are sufficient to slow proliferation. These findings suggest that researchers using doxycycline in inducible expression systems should design appropriate controls to account for potential confounding effects of the drug on cellular metabolism.”

theoretical doxycycline blood concentrations of 0.3 and 0.6 mg/μL obtained 3 hours after low doses might result in 15% change in oxygen(down) and lactate (up)

https://www.ncbi.nlm.nih.gov/pubmed/23741339


https://raypeatforum.com/community/...otics-inhibit-mitochondrial-respiration.6151/
 

tomisonbottom

Member
Joined
Apr 17, 2013
Messages
920
Up to 5omg doesn't create resistance. I'm not 100% sure if that's with doxy, tetra or both, I think both, but you should check.. Maximum suppression of inflammatory cytokines occur at 20-40mg. Tetracyclines suppress respiration in a dose dependent manner. So it depends on your goals, if gut related will depend on flora, pretty unpredictable. I emailed RP about the effects on respiration and he replied that the prescribed doses are perhaps too high.

Contents of a text file I have on the subject, I was interested in migraine/headache.

------
https://www.hindawi.com/journals/mi/2015/329418/
Literature data indicate that the high doxycycline doses (100–200 mg/day) used to treat rosacea correspond to a plasma concentration of 1.5–3 mg/μL, 2-3 hours after oral intake.

From that, we extrapolated the (20–40 mg) oral assumption.

http://www.jaad.org/article/S0190-9622(06)04043-6/abstract

Doxycycline 40 mg Capsules (30 mg Immediate-Release/10 mg Delayed-Release Beads)

Effects of Subantimicrobial-Dose Doxycycline in the Treatment of Moderate Acne

SAGE Journals: Your gateway to world-class journal research

Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3

http://moscow.sci-hub.bz/dc4680d1e83dead83e4f57125acbbf30/[email protected]

Phototoxic eruptions due to doxycycline—a dose‐related phenomenon

Anti-inflammatory Actions of Adjunctive Tetracyclines and Other Agents in Periodontitis and Associated Comorbidities


Based on the non-antimicrobial, anti-inflammatory properties of tetracyclines, a host-modulatory agent comprising a subantimicrobial dose of doxycycline was developed (SDD), as a safe and effective adjunct to conventional non-surgical root surface debridement to treat chronic periodontitis. It has proved to be safe for use at 20 mg b.d for at least 3 months and up to 24 months in randomized placebo controlled clinical trials. It is an approved adjunct in its capacity as an MMP inhibitor of plaque biofilm-induced degradation of tooth-supporting periodontal structures of the dentition. Doxycycline is preferred as a more potent inhibitor of MMPs than tetracyclines. It is safer than minocycline with superior pharmacokinetics which favor improved patient compliance.

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research
Doxycycline alters metabolism and proliferation of human cell lines. - PubMed - NCBI

Doxycycline alters metabolism and proliferation of human cell lines.
Here, we report that in human cell lines, commonly used concentrations of doxycycline change gene expression patterns and concomitantly shift metabolism towards a more glycolytic phenotype, evidenced by increased lactate secretion and reduced oxygen consumption. We also show that these concentrations are sufficient to slow proliferation. These findings suggest that researchers using doxycycline in inducible expression systems should design appropriate controls to account for potential confounding effects of the drug on cellular metabolism.”

theoretical doxycycline blood concentrations of 0.3 and 0.6 mg/μL obtained 3 hours after low doses might result in 15% change in oxygen(down) and lactate (up)
Doxycycline alters metabolism and proliferation of human cell lines. - PubMed - NCBI

The Tetracycline Antibiotics Inhibit Mitochondrial Respiration

Wow..... forgive me if this is a dumb question, but am I to understand there's no benefit to taking over 40mg, and worse, there's increased risk of tanking metabolism when you go over 50 mg?

And did you ever find out if that goes for all tetracyclines?
 

Sucrates

Member
Joined
Jul 20, 2014
Messages
619
Wow..... forgive me if this is a dumb question, but am I to understand there's no benefit to taking over 40mg, and worse, there's increased risk of tanking metabolism when you go over 50 mg?

And did you ever find out if that goes for all tetracyclines?

No. Higher doses have more benefits in some cases but more risks or downsides. I'm not sure where the metabolic cost becomes significant. I haven't done anymore research since that lat post.
 

Similar threads

Back
Top Bottom