Benoxaprofen Reverses MPB. Help Me Identify By What Mechanism?

[GorillaHead]

Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benoxaprofen.

So i am curious to discover the exact mechanism by which this drug is able to reverse MPB. I think it has something to do with 5-LOX inhibition and prostaglandins.


I wish they followed up with the man after he stopped using the drug to see if the hair stayed and slowly went away again.

 

[methylenewhite]

My random guess. It is structurally related to psolaren, known phototoxic compound. And psolaren is used inM in combination with UV light.

 

[GorillaHead]

My random guess. It is structurally related to psolaren, known phototoxic compound. And psolaren is used inM in combination with UV light.

How does that substance lead to hair growth tho?

 

[methylenewhite]

Alopecia areata treatment with a phototoxic dose of UVA and topical 8-methoxypsoralen. - PubMed - NCBI check this

 

[GorillaHead]

Alopecia areata treatment with a phototoxic dose of UVA and topical 8-methoxypsoralen. - PubMed - NCBI check this

so if i understand this correctly.

5-lox inhibitors lead to photo sensitivity which then scalp skin exposed to UV leads to new hair growth Hmm

 

[methylenewhite]

No it's psolaren structure similarity gives benaxoprofen these properties.

 

[GorillaHead]

No it's psolaren structure similarity gives benaxoprofen these properties.

Yes psolaren has been found to inhibit 5LOX


I just dont understand how that leads to hair growth.

After u inhibit 5lox you have more arachidonic acid going to prostaglandins. And then somehow with sun that results in hair growth?


Perhaps the drug increases sensitivity to light. This leads to a sunburn and this leads to wound repair (we know controlled wounding can shrink fibrosis). That can’t be it by itself because many bald people have gotten sun burn son their head and no hair. Maybe high 5lox expression blocks the hair from coming back.

I mean if 5lox inhibition is good for hair wouldn’t they have noticed in trials people’s hairs getting thicker .

@rob have you looked into this ? 5lox inhibitors apparently have powerful anti inflammatory properties