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Beneficial effects and side effects of DHEA: true anti-aging and age-promoting effects, anti-cancer and cancer-promoting effects of DHEA.

AlphaCog

Member
Joined
Jan 28, 2014
Messages
59
The author evaluated the effects of DHEA (Dehydroepiandrosterone) on the amount of telomeres of normal cells and cancer cells and found the following: Contrary to the literature, which often recommended 25-50 mg of DHEA daily for the average adult human being, the author found that, depending on the individual, the maximum increase of normal cell telomere was obtained by a single optimal dose of 1.25-12.5 mg. This was examined in 50 people, both males and females, between the ages of 20-80 years old. When one optimal dose was given to each individual, the average telomere amount in normal tissues, measured in Bi-Digital O-Ring Test units, often increased from anywhere between 25-300 ng to between 500-530 ng. Cancer cell telomere reduced from higher than 1100 ng to less than 1 yg (=10(-24) g) with equally significant normalization of abnormal cancer parameters (such as Integrin alpha5beta1, Oncogen C-fosAb2, Acetylcholine, etc.). Circulatory improvement and an increase in grasping force of up to 25% were also detected, along with the changing of a few white hairs to black hairs. The beneficial effects of one optimal dose of DHEA generally lasted between 1 to 4 months, though in some individuals it lasted for a much shorter period of time due to a number of negative factors such as excessive stress/work, excessive exposure to low temperatures and toxic substances, or use of common pain medicines. On the other hand, if a patient took an excessive dose of DHEA, the amount of normal cell telomere decreased, while there was an increase in cancer cell telomere. It was found that those who took an overdose of 25-50 mg daily for more than 3 months had a high incidence of cancer of the prostate gland, breast, colon, lung, and stomach. Also, when the average normal cell telomere levels were less than 110 ng, compared with a normal value of 120-130 ng, and when DHEA in different parts of the body was also extremely low (less than 1-2 ng), one could suspect the possible presence of a malignant tumor somewhere in the body. When normal cell telomere was less than 110 ng, most individuals felt very weary with marked tiredness in the eyes, and grasping force was often reduced.

 

Beastmode

Member
Joined
Feb 7, 2017
Messages
1,240
Interesting! Again, Peat is onto something years before anyone else. He's the the only person I've ever heard suggest low dose compared to the 50 mg dose and up that is usually suggested by "experts."

Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres

This one is on meditation's effect on telomere length that I sent to Peat a few years ago.

I respond completely different with super low doses of topical DHEA now than when I was hypothyroid.

One still has to address the stress or most of these supplements/hacks won't do much.
 

Lollipop2

Member
Joined
Nov 18, 2019
Messages
4,647
The author evaluated the effects of DHEA (Dehydroepiandrosterone) on the amount of telomeres of normal cells and cancer cells and found the following: Contrary to the literature, which often recommended 25-50 mg of DHEA daily for the average adult human being, the author found that, depending on the individual, the maximum increase of normal cell telomere was obtained by a single optimal dose of 1.25-12.5 mg. This was examined in 50 people, both males and females, between the ages of 20-80 years old. When one optimal dose was given to each individual, the average telomere amount in normal tissues, measured in Bi-Digital O-Ring Test units, often increased from anywhere between 25-300 ng to between 500-530 ng. Cancer cell telomere reduced from higher than 1100 ng to less than 1 yg (=10(-24) g) with equally significant normalization of abnormal cancer parameters (such as Integrin alpha5beta1, Oncogen C-fosAb2, Acetylcholine, etc.). Circulatory improvement and an increase in grasping force of up to 25% were also detected, along with the changing of a few white hairs to black hairs. The beneficial effects of one optimal dose of DHEA generally lasted between 1 to 4 months, though in some individuals it lasted for a much shorter period of time due to a number of negative factors such as excessive stress/work, excessive exposure to low temperatures and toxic substances, or use of common pain medicines. On the other hand, if a patient took an excessive dose of DHEA, the amount of normal cell telomere decreased, while there was an increase in cancer cell telomere. It was found that those who took an overdose of 25-50 mg daily for more than 3 months had a high incidence of cancer of the prostate gland, breast, colon, lung, and stomach. Also, when the average normal cell telomere levels were less than 110 ng, compared with a normal value of 120-130 ng, and when DHEA in different parts of the body was also extremely low (less than 1-2 ng), one could suspect the possible presence of a malignant tumor somewhere in the body. When normal cell telomere was less than 110 ng, most individuals felt very weary with marked tiredness in the eyes, and grasping force was often reduced.

Very interesting thank you!
 

baccheion

Member
Joined
Jun 25, 2017
Messages
2,054
Interesting! Again, Peat is onto something years before anyone else. He's the the only person I've ever heard suggest low dose compared to the 50 mg dose and up that is usually suggested by "experts."

Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres

This one is on meditation's effect on telomere length that I sent to Peat a few years ago.

I respond completely different with super low doses of topical DHEA now than when I was hypothyroid.

One still has to address the stress or most of these supplements/hacks won't do much.
High calcium (+ magnesium) mode goes with lower DHEA. Lower calcium + magnesium goes with higher DHEA.
 

Valor

Member
Joined
May 8, 2022
Messages
5
Location
Oregon
The author evaluated the effects of DHEA (Dehydroepiandrosterone) on the amount of telomeres of normal cells and cancer cells and found the following: Contrary to the literature, which often recommended 25-50 mg of DHEA daily for the average adult human being, the author found that, depending on the individual, the maximum increase of normal cell telomere was obtained by a single optimal dose of 1.25-12.5 mg. This was examined in 50 people, both males and females, between the ages of 20-80 years old. When one optimal dose was given to each individual, the average telomere amount in normal tissues, measured in Bi-Digital O-Ring Test units, often increased from anywhere between 25-300 ng to between 500-530 ng. Cancer cell telomere reduced from higher than 1100 ng to less than 1 yg (=10(-24) g) with equally significant normalization of abnormal cancer parameters (such as Integrin alpha5beta1, Oncogen C-fosAb2, Acetylcholine, etc.). Circulatory improvement and an increase in grasping force of up to 25% were also detected, along with the changing of a few white hairs to black hairs. The beneficial effects of one optimal dose of DHEA generally lasted between 1 to 4 months, though in some individuals it lasted for a much shorter period of time due to a number of negative factors such as excessive stress/work, excessive exposure to low temperatures and toxic substances, or use of common pain medicines. On the other hand, if a patient took an excessive dose of DHEA, the amount of normal cell telomere decreased, while there was an increase in cancer cell telomere. It was found that those who took an overdose of 25-50 mg daily for more than 3 months had a high incidence of cancer of the prostate gland, breast, colon, lung, and stomach. Also, when the average normal cell telomere levels were less than 110 ng, compared with a normal value of 120-130 ng, and when DHEA in different parts of the body was also extremely low (less than 1-2 ng), one could suspect the possible presence of a malignant tumor somewhere in the body. When normal cell telomere was less than 110 ng, most individuals felt very weary with marked tiredness in the eyes, and grasping force was often reduced.

Do you know about research about high endogenous DHEA benefits/risks? If someone's body is naturally producing higher levels of DHEA...?
 

cedric

Member
Joined
Jul 26, 2018
Messages
142
Aromatase is CYP/heme protein, so if someone is iron-overloaded more DHEA will transform into estrogens.
Perhaps it is better before using DHEA to check iron homeostasis.
 

Valor

Member
Joined
May 8, 2022
Messages
5
Location
Oregon
Aromatase is CYP/heme protein, so if someone is iron-overloaded more DHEA will transform into estrogens.
Perhaps it is better before using DHEA to check iron homeostasis.
Excellent information, thank you!
 

Iceman2016

Member
Joined
Jul 12, 2016
Messages
119
Great find. Thanks for posting this.

The beneficial effects of one optimal dose of DHEA generally lasted between 1 to 4 months, though in some individuals it lasted for a much shorter period of time
So, does this mean dosing every day is likely to cause negative effects? According to the above, optimal dosing was one single dose every 1 to 4 months. Am I misunderstanding something?
 
Last edited:

Steve

Member
Joined
Nov 9, 2016
Messages
426
Great find. Thanks for posting this.


So, does this mean dosing every day is likely to cause negative effects? According to the above, optimal dosing was one single dose every 1 to 4 months. Am I misunderstanding something?
That's the concern I had too. I've taking 5 mg daily for over a year now. I have no idea what's that's done to my labs as I need to get some new ones.
 

baccheion

Member
Joined
Jun 25, 2017
Messages
2,054
Does this include supplement imbalance? If a person takes more Mg than Ca, the DHEA can be higher?
Less calcium increases need for DHEA. Also associated with low fat + high carb + neutral/alkaline (low stomach acid) foods. DHEA also lowers stomach acid and bile output.
 

LeeLemonoil

Member
Joined
Sep 24, 2016
Messages
3,415
Excellent information, thank you!
Aromatase is CYP/heme protein, so if someone is iron-overloaded more DHEA will transform into estrogens.
Perhaps it is better before using DHEA to check iron homeostasis.

No one really knows why larger extrinsical dosages of DHEA Are deleterious.

Yes, enzymes likely play a role and the subsequent increased metabolizes. We kind of know that from steroid profile / diseases correlations.

Still, other factors might be at play like direct cellular action of superfluous DHEA.

In any case, Peat operates by „knowing“ thinks intuitively thanks to his vast knowledge and experience. He for decades recommended minuscule dhea doses under 5mg and a few years ago he stopped it entirely going for supplemental testosterone (very low dose) since in age that seems less risky than poorly metabolized dhea.

So I guess peat also thinks the main risk is enzymatic steroid metabolism.

If aromatase is really that much overincreaded when iron is too available I don’t know but still iron overload isn’t a good thingy.
 

dallascat

Member
Joined
Aug 4, 2020
Messages
32
So instead of debating on dosage, since everybody is different, let’s talk about optimal range for DHEA and DHEA-S. I’ve read that men should aim for the 400’s for both. Thoughts?
 

cedric

Member
Joined
Jul 26, 2018
Messages
142
Epsom salt bath?
Vit.A is anti-estrogen, depends on zinc , molybdenum, iron, beta-caroten/sun/b12, albumins
"
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. SHBG is found in all vertebrates apart from birds.[5]

Function[edit]​

Testosterone and estradiol circulate in the bloodstream, loosely bound mostly to serum albumin (~54%), and to a lesser extent bound tightly to SHBG (~44%). Only a very small fraction of about 1 to 2% is unbound, or "free," and thus biologically active and able to enter a cell and activate its receptor. SHBG inhibits the function of these hormones. Thus, bioavailability of sex hormones is influenced by the level of SHBG. The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > estradiol > estrone.[6] DHT binds to SHBG with about 5 times the affinity of testosterone and about 20 times the affinity of estradiol.[7] Dehydroepiandrosterone (DHEA) is weakly bound to SHBG, but dehydroepiandrosterone sulfate is not bound to SHBG.[6] Androstenedione is not bound to SHBG either, and is instead bound solely to albumin.[8] Estrone sulfate and estriol are also poorly bound by SHBG.[9] Less than 1% of progesterone is bound to SHBG.[10]

SHBG levels are usually about twice as high in women than in men.[7] In women, SHBG serves to limit exposure to both androgens and estrogens.[7] Low SHBG levels in women have been associated with hyperandrogenism and endometrial cancer due to heightened exposure to androgens and estrogens, respectively.[7] During pregnancy, due to activation of SHBG production in the liver by high estrogen levels, SHBG levels increase by five-fold to ten-fold.[7] The high SHBG levels during pregnancy may serve to protect the mother from exposure to fetal androgens that escape metabolism by the placenta.[7] A case report of severe hyperandrogenism in a pregnant woman due to a rare instance of genetic SHBG deficiency illustrates this.[7][11][...]

Biochemistry[edit]​

Biosynthesis[edit]​

SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta.[12] Testes-produced SHBG is called androgen-binding protein."
 

Ras

Member
Joined
Sep 12, 2015
Messages
579
The author evaluated the effects of DHEA (Dehydroepiandrosterone) on the amount of telomeres of normal cells and cancer cells and found the following: Contrary to the literature, which often recommended 25-50 mg of DHEA daily for the average adult human being, the author found that, depending on the individual, the maximum increase of normal cell telomere was obtained by a single optimal dose of 1.25-12.5 mg. This was examined in 50 people, both males and females, between the ages of 20-80 years old. When one optimal dose was given to each individual, the average telomere amount in normal tissues, measured in Bi-Digital O-Ring Test units, often increased from anywhere between 25-300 ng to between 500-530 ng. Cancer cell telomere reduced from higher than 1100 ng to less than 1 yg (=10(-24) g) with equally significant normalization of abnormal cancer parameters (such as Integrin alpha5beta1, Oncogen C-fosAb2, Acetylcholine, etc.). Circulatory improvement and an increase in grasping force of up to 25% were also detected, along with the changing of a few white hairs to black hairs. The beneficial effects of one optimal dose of DHEA generally lasted between 1 to 4 months, though in some individuals it lasted for a much shorter period of time due to a number of negative factors such as excessive stress/work, excessive exposure to low temperatures and toxic substances, or use of common pain medicines. On the other hand, if a patient took an excessive dose of DHEA, the amount of normal cell telomere decreased, while there was an increase in cancer cell telomere. It was found that those who took an overdose of 25-50 mg daily for more than 3 months had a high incidence of cancer of the prostate gland, breast, colon, lung, and stomach. Also, when the average normal cell telomere levels were less than 110 ng, compared with a normal value of 120-130 ng, and when DHEA in different parts of the body was also extremely low (less than 1-2 ng), one could suspect the possible presence of a malignant tumor somewhere in the body. When normal cell telomere was less than 110 ng, most individuals felt very weary with marked tiredness in the eyes, and grasping force was often reduced.

I wouldn't put much confidence in the results of this study - the author uses the Bi-digital O-ring test to get his results. This test is a product of applied kinesiology nonsense.
 

CastorTroy

Member
Joined
Apr 17, 2020
Messages
111
Location
Spain
Aromatase is CYP/heme protein, so if someone is iron-overloaded more DHEA will transform into estrogens.
Perhaps it is better before using DHEA to check iron homeostasis.
Shouldn't body fat percentage or fat tissue be a factor on the DHEA converting to estrogen?
 

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