LegendeLic
Member
- Joined
- May 2, 2018
- Messages
- 35
hi! after reading a lot of vitamin D threads in this community and seeing how vitamin D affects others and myself, I am somehow thinking maybe it's just the D3 that is problematic for me and some others?
I have some trouble with D3 it fatigues me and I get a rash depending on the dose. I've tried this a lot of times, it really is the D3. When you search for this here in the forum and elsewhere online you find the same thing over and over again. Doesn't matter how much A, K/K2, magnesium, calcium I or they take with it.
So I am wondering what's the reason for this? Has anyone tried to swap out the D3 against a D2 supplement? And felt different or better?
I did some digging into that and it seems that might be an option for some...
Differential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial
Differential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial
supplementing with D2 lowers D3 and vice versa
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007893/
Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D
Genome-wide association studies have underlined the link between the DBP genotype, circulating levels of DBP, and serum 25D status.
D2 has less affinity to DBP (D binding protein) should result in more free 25-OH-D
https://cjasn.asnjournals.org/content/clinjasn/early/2017/08/01/CJN.00530117.full.pdf
Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD
Vitamin D2 supplementation decreases conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and induces vitamin D3 catabolism as evidenced by changes in D3 metabolites and vitamin D metabolic ratios.
edit: another study... although I am not sure if I am interpreting that wrong or if they are interpreting that wrong.
Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance
Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance
Results: Increases in total (+27.6 vs +12.2 ng/mL; P = .001) and free (+3.6 vs +6.2 pg/mL; P = .02) 25D levels were greater with D3 vs D2.
my conclusions: what? D2 is almost double in free 25 levels than D3 and total half of D3... how can they put that in the same result?
their Conclusions:
D3 increased total and free 25D levels to a greater extent than D2. Free 25D may be superior to total 25D as a marker of vitamin D bioactivity.
I have some trouble with D3 it fatigues me and I get a rash depending on the dose. I've tried this a lot of times, it really is the D3. When you search for this here in the forum and elsewhere online you find the same thing over and over again. Doesn't matter how much A, K/K2, magnesium, calcium I or they take with it.
So I am wondering what's the reason for this? Has anyone tried to swap out the D3 against a D2 supplement? And felt different or better?
I did some digging into that and it seems that might be an option for some...
Differential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial
Differential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial
supplementing with D2 lowers D3 and vice versa
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007893/
Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D
Genome-wide association studies have underlined the link between the DBP genotype, circulating levels of DBP, and serum 25D status.
D2 has less affinity to DBP (D binding protein) should result in more free 25-OH-D
https://cjasn.asnjournals.org/content/clinjasn/early/2017/08/01/CJN.00530117.full.pdf
Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD
Vitamin D2 supplementation decreases conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and induces vitamin D3 catabolism as evidenced by changes in D3 metabolites and vitamin D metabolic ratios.
edit: another study... although I am not sure if I am interpreting that wrong or if they are interpreting that wrong.
Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance
Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance
Results: Increases in total (+27.6 vs +12.2 ng/mL; P = .001) and free (+3.6 vs +6.2 pg/mL; P = .02) 25D levels were greater with D3 vs D2.
my conclusions: what? D2 is almost double in free 25 levels than D3 and total half of D3... how can they put that in the same result?
their Conclusions:
D3 increased total and free 25D levels to a greater extent than D2. Free 25D may be superior to total 25D as a marker of vitamin D bioactivity.
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