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What about being between an UVb and a heat lamp?
It's the cluster that gives the sense of direction, the outlier lives don't matter, in fact I have assassinated a few ones when erasing those lines.
(OH)ase [18], and are able to generate biologically active 1,25(OH)2D3 locally. For example, VDRs are present in most of the human tissues, including in vascular smooth muscle cells [19, 20]. Of relevance, vascular smooth muscle cells also have 1(OH)ase enzyme to be able to produce bioactive metabolite, 1,25(OH)2D3 [18], and thereby can establish a locally active vitamin D circuit that might not be evident from the circulating levels of vitamin D. Similar locally active vitamin D acting ligand-receptor circuit is also detected in other tissues, including in macrophages, monocytes and activated T cells. It is becoming increasingly apparent that all the autocrine, paracrine, and endocrine functions of vitamin D are not always reflected from its serum levels."
What about being between an UVb and a heat lamp?
It's the cluster that gives the sense of direction, the outlier lives don't matter, in fact I have assassinated a few ones when erasing those lines.
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D?
"The levels of vitamin D are clinically estimated from measuring the circulating levels of 25(OH)D, which include circulating forms of both 25(OH)D2 and 25(OH)D3 of the vitamin; yet not all the immunoassays used to measure 25(OH)D in clinical practice can detect 25(OH)D2 [14]. Such technical limitation might be related to a stronger affinity of the vitamin D binding protein (DBP) for 25(OH)D2 [15]. The biochemical assays have wide variability and sensitivities depending on the method used to detect the level of 25(OH)D. Studies have shown that total serum vitamin D [25(OH)D2 + 25(OH)D3] levels, as measured by liquid chromatographytandem mass spectrometry (LC-MS/MS), were lower than the total levels obtained by chemiluminescence assays [16]. It is likely that the cross-reactivity of various vitamin D metabolites such as 24,25(OH)2D3 and 25,26(OH)2D3 may influence the values obtained by the chemiluminescence assays [17]."
"The circulating levels of vitamin D may not always reflect its true values and activities, as there are tissues beyond kidneys that possess an enzymatically active 1
"In addition, race, pigmentation and age can influence the plasma levels of 25(OH)D. [Once again the sun being a racialist, making some of us work harder to obtain the same amount] As mentioned, most of the peripheral tissues are able to process circulating 25(OH)D to the biologically active metabolite 1,25(OH)2D3 to cover their local needs and might not be reflected from its serum levels [18]. Furthermore, because of lipid solubility, supplement-derived vitamin D2 or D3 can be stored in the liver, muscles and fat tissues which would not reflect on serum levels. A major problem in evaluating the earlier studies on the effects of vitamin D status on various organ system is impaired by the wide variability of the results obtained from laboratories that adopt different methods to detect circulating 25(OH)D levels [26, 27]."
"Optimal level of vitamin D is required for physiologic regulations of mineral ion metabolism. It is also involved in modulation of inflammation, cell proliferation and cell differentiation. Vitamin D can induce the expression of various genes [29], thorough interacting with its ubiquitously distributed receptors (VDRs). Numerous studies have shown that serum calcium and phosphate levels increased after intake of high doses of vitamin D supplementation, even when circulating vitamin D level remained low [12]. Such low level of circulating vitamin D is usually used as an evidence of safety by the advocates of vitamin D supplementation."
"It is important to note that vitamin D intoxication following intense UVB exposure is unlikely, as the dermal synthesis of vitamin D is self-regulated process. The dietary consumption of vitamin D usually provides about 10 to 20% of required amount, and therefore vitamin D intoxication by dietary intake is practically not conceivable. Consequently, vitamin D intoxication may only be induced by excessive ingestion of vitamin D supplements [36, 37]. The need and effects of vitamin D supplementation on health are not easy to determine, as circulating levels of 25(OH)D could be influenced by the sunlight exposure and consumption of fortified food. Furthermore, lack of uniform standard makes it harder to compare the published results of the studies that used different 25(OH)D assays [38, 39]. Though, the mean lethal dose (LD50) of vitamin D in humans has been estimated as 21 mg/kg (840,000 IU/kg) [40], in reality, extreme high doses of supplement consumption would rarely raise the vitamin D level that is deemed toxic, and is used as evidence by the advocates of vitamin D supplementation to convince the consumers of taking higher doses supplement for prolonged periods. It is important to mention that, because of lipid solubility, supplement-derived vitamin D2 or D3 can be stored in the liver, muscles and fat tissues and serum vitamin D [25(OH)D] levels would not reflect such storage amount. The features of vitamin D intoxication, including hypercalcemia and/or hypercalciuria, therefore, may persist for months despite the removal of the exogenous source of vitamin D due its lipophilic properties and storage in fat tissues."
"Of clinical importance, the cellular phosphorus burden induced by excessive vitamin D supplementation might contribute to the cellular pathology, even when serum vitamin D levels show hypovitaminosis D status. A wide range of cellular pathology is attributed to cellular phosphorus burden, including necrosis, apoptosis and senescence [47-53]. Available evidences suggest that phosphorus toxicity is a stealth biochemical stress factor that needs greater recognition by researchers and nutrition boards [54]."
Subtle adverse effects are difficult to identify. It took quite a while for people to realize that calcium supplementation can do harm.
But it's impressive how much a person can tolerate:
Vitamin D intoxication: case report
"The patient took a compounded cholecalciferol supplement. Overdose was found by laboratory analysis of the capsules that contained 4,000,000 IU instead of 2,000 IU per capsule. This kind of compounding error may occur mainly when dealing with very-low dose products; in such cases, the pure input is not weighed, it is just diluted."
Vitamin D levels drop by half every two weeks @raypeatclips
I wonder why my arthritic pain in my finger worsens a few hours after ingesting a vitamin D supplement? @burtlancast
That's very interesting, thank you. I might need to increase the dose then. You also mentioned that it's helpful in healing AI conditions. Perhaps it would also help with alopecia. (Ray Peat suggested me to apply it on my eyebrows since they became thinner.)
What do you think of Dr. Peat's statement regarding the ten-fold surplus of iodine through iodized salt?
